Foam or liquid? new study tests best way to treat spider veins
NCT ID NCT07162844
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares two common treatments for spider and reticular veins: liquid sclerotherapy and foam sclerotherapy, both using the drug polidocanol. Some participants will also receive a herbal gel after the procedure. The trial includes 508 adults with mild venous disease (C1) and will measure how much the veins improve in appearance, as well as any side effects. The goal is to find out which method works best and if the herbal gel adds any benefit.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- polidocanol (a sclerosing agent)
- What this could lead to
- If successful, this could help doctors choose the best form of sclerotherapy (liquid or foam) and whether adding herbal gel improves results for spider and reticular veins.
- What could go wrong
- This is a single-center trial with no blinding, so results may be biased. The herbal gel's effect is uncertain, and side effects like bruising or pigmentation changes are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 508 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2024
- Expected to finish
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Sep 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * telangiectasis on thigh or leg side * Competent saphenofemoral and saphenopoliteal junction * Patient post surgical stripping or post thermal ablation * clinical classification of chronic venous disease C1(mild venous disease), - * minimum age of 18 year-old and maximum age 65 year-old - Exclusion Criteria: * varicose disease in any quantity or location with clinical classification of chronic venous * disease different of C1(mild venous disease) * arterial insufficiency * patient allergic to the sclerosant material or herbal gel * dermatitis on application site * patient with serious comorbidities like heart failure, respiratory failure, - uncontrolled hypertension with medication, and uncontrolled hypothyroidism - pregnancy - previous deep vein thrombosis (DVT) - family history of DVT - thrombophilia
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Faculty of medicine kfs university
Kafr ash Shaykh, Kafr el-Sheikh Governorate, 33511, Egypt
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