Blood test could spot testicular cancer earlier
NCT ID NCT07376096
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study explores whether a liquid biopsy—a blood test that looks for tumor DNA and micro RNA—can detect and monitor testicular germ cell tumors. Researchers will collect blood samples from 200 men with stage I or metastatic testicular cancer at several time points during treatment. The goal is to see if this test can help diagnose the disease and predict outcomes, especially for patients who do not have standard tumor markers.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- liquid biopsy (blood test for circulating tumor DNA and micro RNA)
- What this could lead to
- If successful, this could provide a simple blood test to detect and monitor testicular cancer, especially for patients who lack standard tumor markers.
- What could go wrong
- This is an early-stage study with only 200 participants, and the test may not be accurate enough to replace current methods. It is not yet proven to work in routine care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
We aim to recruit 200 testicular germ cell tumor patients, 100 subjects with metastatic disease and 100 patients with stage I disease.
- Ages
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18 years and older
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male patients with the age ≥ 18years with * Seminomatous or non-seminomatous germ cell tumors (extragonadal origin is allowed) * Metastatic disease * Stage I patients on active surveillance (for seminoma patients at least one risk factor, rete testis infiltration or tumor size \> 4cm, should be present) Exclusion Criteria: * Other tumors than germ cell tumors of the testis * Patients with a second malignancy within the last 5 years (except germ cell tumors) * Stage I patients who received adjuvant treatment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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Other studies related to the condition(s) this trial covers.
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