Can a Color-Enhanced scope catch what white light misses?
NCT ID NCT07745842
First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time
Summary
This trial tests whether a special light mode called linked color imaging (LCI) helps doctors find more sessile serrated lesions (a type of precancerous colon polyp) during colonoscopy than standard white light. About 2,000 adults aged 45 and older having their first screening colonoscopy will be randomly assigned to have the procedure done in two passes, with the order of light modes switched. The goal is to see if LCI reduces the number of lesions missed on the first look.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- linked color imaging (LCI) during colonoscopy
- What this could lead to
- If LCI proves better at spotting these lesions, it could lead to more accurate colonoscopies and potentially lower colorectal cancer risk.
- What could go wrong
- The benefit may be small or not consistent across different doctors and centers. Also, the trial is not yet complete, so results are uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 2,072 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subjects aged ≥45 years, regardless of gender; 2. Subjects undergoing screening colonoscopy; 3. Subjects with no prior colonoscopy; 4. Voluntarily provide written informed consent. Exclusion Criteria: 1. Subjects unable to cooperate with or tolerate colonoscopy; 2. Subjects with inflammatory bowel disease; 3. Known or highly suspected colorectal obstruction; 4. History of colorectal surgery; 5. Chronic recurrent constipation; 6. Failure to discontinue anticoagulants or antiplatelet agents for at least 1 week before the procedure; 7. Poor bowel preparation with an inadequate Aronchick scale score during colonoscopy; 8. Failed cecal intubation; 9. High-risk conditions including severe cardiovascular and cerebrovascular diseases, uncorrected severe anemia or active infection; 10. Pregnant or breastfeeding women; 11. Subjects deemed ineligible for participation in this trial at the investigator's discretion.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.