Lidocaine spray may replace fentanyl for tube insertion stress
NCT ID NCT07533643
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested if a lidocaine spray and mouth rinse before surgery could reduce stress from inserting a breathing tube, compared to a standard IV painkiller (fentanyl). 50 adults having elective surgery participated. The goal was to see which method better controlled blood pressure changes right after tube placement.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Aug 2025
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * American society of anaesthesiologists class 1 or 2 (ASA 1 or 2) patients. * Patients undergoing elective surgeries under general anaesthesia with endotracheal intubation using direct laryngoscope. * Population aged from 18 to 60 years. Exclusion Criteria: * Patient's refusal to participate. * ASA class 3 or more patients including Substantive functional limitations; One or more moderate to severe diseases. Poorly controlled DM or HTN, COPD, morbid obesity (BMI ≥40), active hepatitis, alcohol dependence or abuse, implanted pacemaker, reduction of ejection fraction, ESRD undergoing regularly scheduled dialysis, history of MI, CVA, TIA, or CAD/stents, asthma with exacerbation, poorly controlled epilepsy. * Patients with any degree of Hypertension or treated for hypertension. * Pregnant patients. * Age of participant less than 18 or more than 60 years. * History of allergy to local anaesthetics or opioids. * Opioid abuse * Anticipated difficult airway which will be defined as El-Ganzouri Risk Index (EGRI) score of 4 or more points. * Difficult intubation which will be defined as situation where proper insertion of the tracheal tube with conventional laryngoscopy requires more than three attempts or more than 10 min. * Difficult mask ventilation which will be defined as a situation that develops when it is not possible for the unassisted anaesthesiologist to maintain the oxygen saturation \>90% using 100% oxygen and positive pressure ventilation, or to prevent or reverse signs of inadequate ventilation. * Patients requiring more than one attempt of intubation. * Intubation time more than 30 seconds. * Emergency surgeries or patients requiring rapid sequence induction for other reasons.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Kasr Alainy Medical School
Cairo, Egypt