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Toothache showdown: lidocaine vs articaine – which numbing drug wins?

NCT ID NCT07231614

Symptom relief Sponsor: Universidad Austral de Chile Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two common numbing medicines used in dentistry: lidocaine and articaine. One hundred adults needing a simple tooth removal will be randomly assigned to receive one of the two. The goal is to see which medicine controls pain better and reduces the need for extra numbing shots, helping dentists choose the best option for each patient.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Jan 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with clinical indications for simple extraction of upper and lower teeth using infiltrative anesthetic techniques. * Patients without systemic diseases (ASA I) * Patients with controlled systemic disease (ASA II) * Patients with no history of hypersensitivity to anesthetics or their components (epinephrine) * Patients with stable periodontal condition, without active infection that could affect the diffusion of the anesthetic. * Patients with the ability to understand the procedure and provide informed consent. Exclusion Criteria: * Patients with uncontrolled systemic diseases ASA III and pregnant patients. * Patients requiring trunk techniques (Gow gates, Spix, Carrea) * Patients taking medication that affects the anesthetic response (tricyclic antidepressants, anticoagulants) * Patients with a history of neurological or psychiatric disorders that may influence the perception of pain or anxiety. * Patients with anatomical abnormalities in the orofacial region that interfere with the administration or action of anesthesia. * Patients with a history of recent substance abuse.

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Conditions

The condition(s) this trial relates to.

Toothache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CESFAM Dr. Jorge Sabat

    Valdivia, Los Ríos Region, 5090000, Chile

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