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A monthly ring could put birth control on autopilot — a trial puts it to the test

NCT ID NCT07734155

Disease control Sponsor: Chemo Research Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether a levonorgestrel vaginal ring, worn continuously for 28 days, can effectively prevent pregnancy in females aged 13 to 45 who are sexually active and able to conceive. Researchers will track pregnancies and side effects over about 13 months of use. The goal is to see if this monthly ring offers a safe and reliable contraceptive option.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a levonorgestrel vaginal ring worn continuously for 28 days per cycle
What this could lead to
If successful, this could offer a new, convenient long-acting contraceptive option that women use for a month at a time.
What could go wrong
This is a single-arm, open-label trial without a comparison group, so results may be less definitive. Side effects like irregular bleeding or hormonal changes are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,600 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion: * Female between age 13 and 45 years * Sexually active and of child-bearing potential * Not pregnant with regular menstrual cycles * Blood pressure: ≤ 140 mmHg systolic and ≤ 90 mmHg diastolic Exclusion: * Pregnant or desire of pregnancy * Amenorrhea * History of infertility or menopause or reproductive sterility * Male sexual partner with infertility/sterility * Known bleeding disorder or history of unknown bleeding/bruising * Abnormal clinically significant findings on laboratory tests, physical, pelvic, breast, or ultrasound examination * Papanicolaou (Pap) smear reading of low-grade squamous intraepithelial lesion (LSIL) or higher at screening * History of: VTE, cardiovascular disease, major surgeries, diabetes mellitus, severe hepatic disease, renal insufficiency, adrenal insufficiency, sex steroid sensitive malignancy, breast cancer, HPV infections * Uncontrolled chronic disease * Severe DOCID-19 * Progestin releasing IUD use, implant contraception use * Planned regular use of barrier contraceptive methods, spermicide, IUDs, other contraceptive measures

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Conditions

The condition(s) this trial relates to.

Contraception Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contraceptive usage

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.