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Could a breast cancer drug treat ectopic pregnancy?

NCT ID NCT07624903

Disease control Sponsor: Kafrelsheikh University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether letrozole, a drug that lowers estrogen, can treat early ectopic pregnancy as effectively as the standard drug methotrexate. The trial will enroll 70 women with confirmed ectopic pregnancy and low hormone levels. Participants will receive one of the two drugs, and success will be measured by how well the pregnancy resolves.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Letrozole (a drug that blocks estrogen production) and methotrexate (a drug that stops cell growth)
What this could lead to
If letrozole works as well as methotrexate, it could offer a simpler, less toxic treatment option for early ectopic pregnancy, avoiding surgery.
What could go wrong
This is a small, early-phase trial with only 70 participants. It may not show a clear benefit, and letrozole's safety for this use is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 35 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Confirmed ectopic pregnancy on trans vaginal ultrasound * Age between 20 and 35 years * A β-hCG levels \< 3000 Iu/ L * The average diameter of the adnexal mass ≤3.5 cm * Stable hemodynamic condition Exclusion Criteria: * Presence of fetal heart pulsation * Heterotopic pregnancy * Presence of significant abdominal pain * history of allergic reactions to MTX or letrozole * Any known liver disorder or abnormal liver enzyme levels (AST or ALT ) * Any known renal disorder or impaired renal function tests (abnormal creatinine)

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Conditions

The condition(s) this trial relates to.

ectopic pregnancy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ectopic pregnancy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kafr El-Sheikh University

    Kafr ash Shaykh, Kafr el-Sheikh Governorate, 33511, Egypt

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