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Can a new sleep drug help chest surgery patients rest better?

NCT ID NCT07811401

Symptom relief Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers are testing whether lemborexant, a sleep medication, improves sleep quality for adults recovering from video-assisted thoracoscopic surgery. The trial enrolls 130 patients aged 18 to 70 who are scheduled for this minimally invasive chest operation. Participants receive either lemborexant or a placebo three times around surgery, and researchers measure sleep quality the night after surgery using a questionnaire, along with pain and recovery markers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lemborexant, a sleep-promoting drug
What this could lead to
If it works, this could give chest-surgery patients a sleep aid that does not slow breathing or leave them groggy, helping them recover faster.
What could go wrong
This is a mid-stage trial in a specific surgical group, so results may not apply to other patients or surgeries. Lemborexant can cause next-day drowsiness in some people, and the placebo comparison may show little difference.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 130 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged between 18 and 70 years; * ASA I-III; * Patients scheduled to undergo elective video-assisted thoracoscopic surgery (VATS) under general anaesthesia, including wedge resection, segmentectomy and lobectomy; * Expected post-operative hospital stay of ≥3 days; * Signing of a written informed consent form. Exclusion Criteria: * Patients whose surgery is expected to finish after 19:00, or who will remain intubated post-operatively or require admission to the ICU; * Patients with a pre-operative diagnosis of moderate to severe obstructive sleep apnoea (OSA); * Patients with pre-existing sleep disorders or those taking sedatives, hypnotics or antidepressants on a long-term basis; * Patients with moderate to severe hepatic or renal impairment; * Patients with cognitive impairment preventing them from cooperating with scale-based assessments; * Patients with pre-existing chronic neuropathic pain; * Patients unsuitable for or refusing to participate in this study for other. reasons.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative sleep disturbance Thoracoscopic surgery

How to take part

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  1. The official record

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