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Could vinegar and a laser beat tooth infections in diabetes?

NCT ID NCT07549373

Disease control Sponsor: Sharda University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a diode laser, apple cider vinegar, or the herb Gymnema Sylvestre can better disinfect root canals in people with type 2 diabetes who have a tooth infection called apical periodontitis. Ninety participants will be split into groups receiving different combinations of these treatments during root canal therapy. The goal is to see which approach best kills bacteria and reduces pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
940nm diode laser, apple cider vinegar, Gymnema Sylvestre
What this could lead to
If successful, this could point toward a simple, low-cost way to improve root canal disinfection in diabetic patients, reducing infection and pain.
What could go wrong
This is a small, early-stage trial (90 participants) testing multiple interventions. Results may not apply to all patients, and the long-term effectiveness is unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Using radiographs, intraoral periapical radiographs (RVG) primary endodontic infection will be selected. * Multirooted teeth , root with periapical lesion will be selected * Type 2 diabetics between the ages of 25 years and 60 years will be chosen; both male and female patients * A fasting blood sugar level of 126 mg/dl and a random blood sugar level of less than 200 mg/dl * HbA1c (glycated haemoglobin) ≥ 6.5% Exclusion Criteria: * Patients with systemic conditions other than type 2 diabetes * Women who are pregnant * Those patients that have used antibiotics within the previous three months, * Those patients that have teeth with developmental defects, calcified canals, * Teeth that cannot be isolated with rubber dams, * Tortuous canals * Roots that are fractured

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Conditions

The condition(s) this trial relates to.

periapical periodontitis type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabete type 2

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dr Lakshmi Pandey

    RECRUITING

    Noida, Uttar Pradesh, 201310, India

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