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Could a laser zap away tooth pain? new trial tests combo treatment

NCT ID NCT07449169

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two treatments for dentin hypersensitivity (tooth sensitivity). One group gets a special varnish (CPP-ACPF) alone, the other gets the varnish plus a low-level laser treatment. 70 adults with sensitive teeth will rate their pain before and after. The goal is to see if adding the laser provides extra relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
diode laser photobiomodulation and CPP-ACPF varnish
What this could lead to
If it works, this could offer a more effective, non-invasive option for managing tooth sensitivity.
What could go wrong
This is a small, early-stage trial (70 people) comparing two treatments, so results may not apply broadly. The laser adds cost and time, and the benefit over varnish alone is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult participants aged from 20 to 50 years of age. * Participants with good oral hygiene. * Presence of at least one tooth with dentin hypersensitivity confirmed by the air blast and/or tactile stimuli (scoring ≥3 on the VAS). * Participants willing to cooperate and attend recall appointments * Teeth with Non-Carious Cervical Lesions. * Patients with dentin hypersensitivity due to GERD and Parafunctional habits e.g., bruxism. * Patients with dentin hypersensitivity associated with gingival recession. Exclusion Criteria: * Participants with poor oral hygiene. * History of professional or at-home desensitizing treatment within the previous 3 months. * Pregnant or lactating females. * Concurrent participation in other research studies. * Inability to comply with study procedures. * History of allergic reactions to study materials. * Medical conditions interfering with pain reporting accuracy (pain disorders, constant use of analgesics, anti-inflammatory, or psychotropic medications). * History of periodontal surgeries within the last six months. * Periodontitis and pulpitis.

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Conditions

The condition(s) this trial relates to.

dentin sensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dentin hypersensitivity Tooth hypersensitivity

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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More trials for these conditions

Other studies related to the condition(s) this trial covers.