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New combo therapy aims to ease stubborn back pain without drugs

NCT ID NCT07556926

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study will test whether adding high-intensity laser therapy to a hands-on technique called Mulligan mobilization can reduce pain and improve movement in people with chronic low back pain. Fifty adults aged 18-60 will be split into two groups: one gets the combo treatment, the other gets mobilization alone. The goal is to see if the combination works better for pain, disability, and range of motion.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High-intensity laser therapy and Mulligan mobilization
What this could lead to
If it works, this could point toward a more effective non-drug treatment for chronic low back pain.
What could go wrong
This is a small pilot study (50 people) that hasn't started yet, so results are uncertain. The combined approach may not prove better than mobilization alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female participants aged 18-60 years * Diagnosis of chronic non-specific low back pain (pain persisting for ≥3 months) * Pain localized between the lower costal margins and gluteal folds, with or without referred pain * Baseline pain intensity of ≥3 on the Numeric Pain Rating Scale (NPRS) * Ability to understand and follow instructions and provide informed consent * Not currently receiving other forms of physiotherapy or structured treatment for low back pain during the study period Exclusion Criteria: * Specific spinal pathology (e.g., fracture, tumor, infection, inflammatory diseases such as ankylosing spondylitis) * History of spinal surgery * Neurological deficits or signs of nerve root compression (e.g., severe radiculopathy) * Pregnancy * Severe osteoporosis or other contraindications to manual therapy * Contraindications to high-intensity laser therapy (e.g., malignancy in the treatment area, photosensitivity disorders) * Current use of medications that significantly affect pain perception (e.g., high-dose opioids) * Participation in another clinical trial within the last 3 months

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Conditions

The condition(s) this trial relates to.

Low Back Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Middle East University

    Amman, Jordan

More trials for these conditions

Other studies related to the condition(s) this trial covers.