New laser zaps freckles just as well as old one, study finds

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 to 65 years (inclusive). * Fitzpatrick skin type III, IV, or V. * Diagnosed with facial freckles. * Presence of visually symmetrical bilateral facial freckles. * Able to understand and voluntarily sign the informed consent form. * Willing and able to comply with all study procedures and follow-up visits. Exclusion Criteria: * High photosensitivity to any light spectrum. * Severe organic diseases (e.g., epilepsy, psychosis). * History of sunburn within the past 1 month. * History of skin malignancies (e.g., squamous cell carcinoma, melanoma). * Skin lesions that are broken, inflamed, or with a history of poor wound healing or keloids. * Diagnosis of cutaneous lupus erythematosus. * Significant systemic disease or obvious lesions in the treatment area. * Presence of herpes simplex virus (HSV) in the expected treatment area. * Active local or systemic infection, or open wounds in the treatment area. * History of immunosuppression/immunodeficiency (including HIV/AIDS) or use of immunosuppressive drugs. * Use of anticoagulants or medications that may alter wound healing within the past 1 month. * Use of known photosensitizing medications within the past 1 month. * Oral isotretinoin (Accutane) use within 12 months prior to initial treatment or planned use during the study. * Use of iron supplements, herbal supplements (e.g., Ginkgo, Ginseng, Garlic), or fish oil supplements within the past 1 month. * Other photo or energy-based aesthetic procedures in the treatment area within the past 1 month. * Pregnancy, lactation, or planning pregnancy during the study period. * Participation in another clinical trial (except registry studies) within 3 months prior to screening. * Considered by the investigator to have poor compliance or otherwise unsuitable for participation.