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Laser showdown: which eye surgery fixes mixed astigmatism best?

NCT ID NCT07481227

Symptom relief Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two types of laser eye surgery—FS-LASIK and single-step TransPRK—for correcting mixed astigmatism, a condition where the eye's shape causes blurry vision at all distances. Thirty-nine people received one of the two procedures, and researchers measured their vision and prescription afterward. The goal was to see which surgery provides better visual outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Femtosecond laser-assisted LASIK and single-step transepithelial photorefractive keratectomy (laser eye surgery procedures)
What this could lead to
If successful, this could help doctors choose the best laser surgery for people with mixed astigmatism, leading to clearer vision without glasses.
What could go wrong
This is a small, completed study with only 39 participants, so results may not apply to everyone. Both procedures carry standard risks like dry eyes or under-correction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

39 people

The number who actually took part.

Started

Jun 2019

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This was a retrospective comparative study conducted at Tiba eye center (private practice). The study reviewed and analyzed the records of patients with mixed astigmatism who underwent femtosecond laser-assisted LASIK (FS-LASIK group) or single-step TransPRK (TransPRK group) and completed 24 months of follow-up.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Mixed astigmatism (Plus sphere up to +4 diopters D and a minus cylinder up to -6 D). * Stable refraction. * Clear cornea. * Normal corneal tomography. Exclusion Criteria: * Corrected distance visual acuity worse than 20/32 Snellen's acuity. * Difference between manifest and cycloplegic refraction ≥ 1 D. * Previous corneal or ocular surgeries, other ocular diseases. * Systemic diseases including diabetes mellitus and autoimmune diseases.

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Conditions

The condition(s) this trial relates to.

astigmatism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mixed astigmatism

Contacts and locations

Locations

  • TIBA Eye Center

    Asyut, Asyut Governorate, 71515, Egypt