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Keyhole vs open surgery for colon cancer: which is better?

NCT ID NCT05713903

Disease control Sponsor: Larissa University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compares laparoscopic (keyhole) surgery to open surgery for removing the right side of the colon in people with right colon cancer. Both methods follow a precise technique called complete mesocolic excision (CME) to ensure thorough removal. The trial will enroll 114 adults aged 18-90 and measure how well each surgery removes the cancer, as well as recovery and complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Laparoscopic right colectomy or open right colectomy, both following complete mesocolic excision (CME) principles
What this could lead to
If successful, this could show that laparoscopic surgery is as effective as open surgery for removing right colon cancer, potentially leading to less invasive treatment.
What could go wrong
This is a relatively small trial (114 participants) and results may not apply to all patients. The study focuses on surgical technique quality, not long-term survival, so benefits may be limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 114 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2023

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically confirmed right colon cancer (cecum, ascending colon, hepatic flexure) * Surgical resection based on the CME principles * Patient 18 to 90 years old * American Society of Anesthesiologists score ≤III * Τ≤3 * Elective operation * Signed informed consent of the patient Exclusion Criteria: * Non elective operation (hemorrhage, perforation, obstruction) * Locally advanced disease (T4) * Distant metastases (Stage IV) * American Society of Anesthesiologists ≥IV * Previous laparotomy * BMI \>35 kg/m2 * Active sepsis or systemic infection * Untreated physical and mental disability * Pregnancy or breast-feeding * Lack of compliance with the protocol process * Non-granting of signed informed consent

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Conditions

The condition(s) this trial relates to.

ascending colon cancer colon carcinoma colonic neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colon cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Surgery, University Hospital of Larissa

    RECRUITING

    Larissa, 41110, Greece

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