Probiotic shows promise for weight and hormone health in women
NCT ID NCT07502404
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a probiotic called Lactobacillus gasseri could help overweight women manage their weight and balance sex hormones. Over 12 weeks, 110 women took either the probiotic or a placebo. Researchers measured changes in estrogen levels and body fat. The goal was to see if this friendly bacteria could support weight management and endocrine health.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Lactobacillus gasseri probiotic
- What this could lead to
- If it works, this could point toward a natural supplement to help with weight management and hormone balance in overweight women.
- What could go wrong
- This is a small, completed trial with 110 women. Results may not apply to everyone, and the effect may be modest. Probiotics can cause mild digestive upset in some people.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
110 people
The number who actually took part.
- Started
-
Apr 2025
- Finished
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Oct 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: (1) female sex, aged 18-50 years; (2) body mass index (BMI) ≥ 25 kg/m2; (3) willingness to maintain habitual dietary intake and physical activity patterns throughout the study period and to comply with follow-up visits, sample collection, and questionnaire completion; (4) ability to complete blood sampling during the early follicular phase of the menstrual cycle (days 3-5), as confirmed by self-reported menstrual timing. \- Exclusion Criteria: (1) pregnancy or lactation; (2) presence of chronic diseases or endocrine/metabolic disorders (e.g., diabetes mellitus, thyroid disorders); (3) recent use of medications or dietary supplements that could affect endocrine or metabolic function; (4) non-compliance with the required washout period or prohibited use of probiotic products during the study; (5) any other conditions deemed by the investigators to be unsuitable for participation. \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fuwai Central-China Cardiovascular Hospital
Zhengzhou, Henan, 462000, China
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