CO2 clue may help doctors treat shock patients better
NCT ID NCT05032521
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether using a CO2-based algorithm to guide treatment of high lactate in patients with acute circulatory failure works better than standard care. 180 adults in intensive care were randomly assigned to either usual treatment or treatment guided by CO2 measurements. The main goal was to see if more patients in the CO2-guided group had a significant drop in lactate levels within 2 hours.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- standard drugs (vasopressors, inotropes, fluids) guided by a CO2-based algorithm
- What this could lead to
- If successful, this approach could help doctors choose the right treatment for shock patients with high lactate, potentially improving outcomes.
- What could go wrong
- This is a single-center, Phase 4 trial with 180 participants. The algorithm may not improve lactate clearance or patient outcomes, and results may not apply to all shock patients.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
180 people
The number who actually took part.
- Started
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Nov 2021
- Finished
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Nov 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Oral, free and informed consent obtained from a trusted person (health care proxy) or a close relative or consent in an emergency situation * Adult patient managed in intensive care for whom the physician has decided on hemodynamic management because of signs of acute circulatory failure (systolic blood pressure \< 90 mmHg, mean arterial pressure \< 65 mmHg, or the need for infusion of vasopressors, skin mottling, diuresis \< 0.5 mL/kg/h for a duration ≥ 2 hours, skin recoloring time \> 3 sec * Arterial lactate level ≥ 3 mmol L-1 Exclusion Criteria: * Person not affiliated to national health insurance * Person subject to a measure of legal protection (curatorship, guardianship) * Person subject to limited judicial protection * Pregnancy or breastfeeding
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Chu Dijon Bourgogne
Dijon, 21000, France
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