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Lactate may rejuvenate aging brains by boosting glucose use

NCT ID NCT07731451

Knowledge-focused Sponsor: Northern Arizona University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This early-phase trial tests whether lactate—a fuel produced during exercise—can improve how the aging brain uses glucose. Healthy young and older adults will receive lactate via infusion or cycling to see if it restores youthful brain metabolism. The goal is to understand if lactate can protect the brain from age-related decline and Alzheimer's disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sodium lactate infusion and exercise-induced hyperlactatemia
What this could lead to
If lactate helps older brains use glucose more efficiently, it could point toward a way to maintain brain health and reduce the risk of Alzheimer's disease.
What could go wrong
This is a very early, small study in healthy, fit volunteers. Results may not apply to less active or cognitively impaired people, and the effects of lactate may not persist long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Meet the American College of Sports Medicine (ACSM) physical activity guidelines for moderate-intensity aerobic activity, i.e., 150+ minutes of moderate or 75+ minutes of rigorous aerobic activity. * The older cohort must have adhered to these physical activity guidelines for 30+ years. * "Good" or "Excellent" aerobic fitness category based on ACSM standardized maximal aerobic power (V̇O2max) values for age and sex. Exclusion Criteria: * Need for daily medication for chronic conditions, diagnosed heart, lung, metabolic or cerebrovascular disease, smokers, pregnancy and women in perimenopause are exclusion criteria; these will be verified with questionnaires and preliminary screening. * Significant carotid plaque will be excluded via ultrasound assessment. * Evidence of mild cognitive impairment (MCI) * Personal complaints of memory deficits, clinical diagnosis, or evidence from the NIH ToolBox ®V3 will be considered signs of MCI. * Adverse responses to maximal exercise, or an inability to complete maximal exercise during fitness screening will also be exclusion criteria. * known allergy to Lidocaine also cannot participate.

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Conditions

The condition(s) this trial relates to.

Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Aging well

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Northern Arizona University Dept of Biological Sciences

    Flagstaff, Arizona, 86011, United States

More trials for these conditions

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