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Could a blood clot help your jawbone heal faster for implants?

NCT ID NCT07387913

Disease control Sponsor: National and Kapodistrian University of Athens Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a membrane made from a patient's own blood (L-PRF) can improve bone healing after a tooth is pulled, compared to standard bone graft materials or natural healing. Forty adults who need a single-rooted tooth extracted are randomly assigned to one of four socket treatments. After three months, the researchers measure bone changes with CT scans and examine bone samples under a microscope to see which method works best for preparing the jaw for a dental implant.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Leukocyte Platelet-Rich Fibrin (L-PRF) membrane
What this could lead to
If it works, this could lead to faster and stronger bone healing after tooth extraction, allowing earlier and more successful dental implant placement.
What could go wrong
This is a small, early-stage study with only 40 participants. Results may not apply to everyone, and L-PRF may not prove better than standard treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2022

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Single-rooted teeth needed to be extracted in the maxilla or mandible 2. Patient in good general health as documented by self-assessment 3. Patients must be committed to the study and sign the informed consent 4. Adults only as participants Exclusion Criteria: 1. No systemic medical condition that could interfere with the surgical procedure or planned treatment. 2. Smokers \>20 cig/day 3. Current pregnancy or breast feeding 4. Radiotherapy or chemotherapy in head and neck area intravenous and oral bisphosphonates or anti-angiogenic drugs

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar bone grafting Dental implants L-PRF Osseointegration

Contacts and locations

Locations

  • Athens Univeristy Dental School

    Athens, 11527, Greece

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