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Natural supplement vs. little blue pill: which works better for ED?

NCT ID NCT07642505

Symptom relief Sponsor: Beni-Suef University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a natural supplement called L-citrulline can improve mild to moderate erectile dysfunction as well as the standard drug tadalafil (Cialis), and whether taking both together works even better. About 133 men aged 30-70 will take one of three treatments daily for 12 weeks. Researchers will measure changes in erectile function scores and track side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
L-citrulline and tadalafil
What this could lead to
If it works, this could show that a natural supplement (L-citrulline) is as effective as a standard ED drug, or that combining them works better than either alone.
What could go wrong
This is a small, early-phase trial (133 men) comparing a supplement to an established drug. The supplement may not work as well, and results may not apply to all men with ED.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 133 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 70 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male patients aged 30 to 70 years. * Erectile dysfunction for at least 3 months. * Mild to moderate erectile dysfunction, defined by International Index of Erectile Function-Erectile Function domain score from 11 to 25. * Stable sexual relationship during the study period. * Willingness to attempt sexual activity during the study period. * Ability to complete study questionnaires and attend follow-up visits. * Written informed consent. Exclusion Criteria: * Severe erectile dysfunction, defined by International Index of Erectile Function-Erectile Function domain score of 10 or less. * Current nitrate or nicorandil use. * Contraindication or hypersensitivity to tadalafil or L-citrulline. * Unstable cardiovascular disease, unstable angina, recent myocardial infarction or stroke, uncontrolled hypertension, or high-risk arrhythmia. * Severe hepatic impairment. * Severe renal impairment. * Untreated hypogonadism requiring hormonal treatment. * Hyperprolactinemia or uncontrolled endocrine disorder. * Major neurogenic erectile dysfunction, spinal cord injury, or previous radical pelvic surgery causing severe erectile dysfunction. * Significant Peyronie's disease preventing intercourse. * Active major psychiatric illness impairing reliable assessment. * Use of phosphodiesterase type 5 inhibitors, intracavernosal injection therapy, vacuum device therapy, testosterone therapy, L-arginine, L-citrulline, or erectile dysfunction nutraceuticals during the washout period before randomization. * Participation in another clinical trial during the previous 3 months.

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Conditions

The condition(s) this trial relates to.

erectile dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Erectile dysfunction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Urology- Beni-Suef University Hospitals

    RECRUITING

    Banī Suwayf, Beni Suweif Governorate, 02456, Egypt

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