New combo therapy aims to shrink hard-to-treat gut tumors
NCT ID NCT07406633
First seen Feb 21, 2026 · Last updated May 22, 2026 · Updated 8 times
Summary
This study tests whether adding an experimental drug, KQB198, to the standard cancer drug imatinib is safe and works better for people with advanced gastrointestinal stromal tumor (GIST). About 46 adults with a specific gene mutation (KIT or PDGFRA) will receive the combination as their first treatment for advanced disease. The main goal is to see if tumors shrink or disappear.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98195, United States
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Mayo Clinic - Jacksonville
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic - Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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USC Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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UT MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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University of Michigan Hospitals
RECRUITINGAnn Arbor, Michigan, 48109, United States
Conditions
Explore the condition pages connected to this study.