New hope for Hard-to-Treat blood cancers?

NCT ID NCT06645886

Ongoing Disease control Sponsor: Kumquat Biosciences Inc. Source: ClinicalTrials.gov ↗

First seen Nov 06, 2025 · Last updated May 23, 2026 · Updated 35 times

Summary

This early-phase trial tests a new drug called KQB198, alone or with other cancer medicines, in adults with advanced blood cancers that have not responded to prior treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. About 13 participants will take the drug daily and have frequent clinic visits for monitoring.

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Contacts and locations

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Locations

AP-HM - Hopital de la Timone

Marseille, 13005, France
ASST Grande Ospedale Metropolitano Niguarda

Milan, Lombardy, 20162, Italy
Aidport Sp. z o.o.

Poznan, Greater Poland Voivodeship, 60-185, Poland
Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
CHRU de Tours - Hopital Bretonneau

Tours, Centre-Val de Loire, 37044, France
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Copernicus PL Sp. z o.o., Wojewodzkie Centrum Onkologii

Gdansk, Pomeranian Voivodeship, 80-214, Poland
Duke University Medical Center

Durham, North Carolina, 27710, United States
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano

Milan, Milan, Lombardy, 20122, Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore

Rome, Lazio, 00168, Italy
Hammersmith Hospital

London, Greater London, W12 0HS, United Kingdom
Hospital Regional Universitario de Malaga

Málaga, Andalusia, 29010, Spain
Hospital Universitario 12 de Octubre

Madrid, Madrid, 28041, Spain
Hospital Universitario La Paz

Madrid, Madrid, 28046, Spain
IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant Orsola

Bologna, Bologna, 40138, Italy
Institut Catala d'Oncologia - L'Hospitalet

L'Hospitalet de Llobregat, Catalonia, 08908, Spain
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Medizinische Hochschule Hannover (MHH)

Hanover, Lower Saxony, 30625, Germany
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Nottingham University Hospitals

Nottingham, Nottinghamshire, NG5 1PB, United Kingdom
Oncology Hematology Cincinnati

Cincinnati, Ohio, 45236, United States
Pratia Onkologia Katowice

Katowice, Silesian Voivodeship, 40-519, Poland
Sarah Cannon Research Institute (SCRI) - Transplant and Cellular Therapy Operations

Nashville, Tennessee, 37203, United States
Stichting Radboud Universitair Medisch Centrum

Nijmegen, Gelderland, 6525, Netherlands
Texas Oncology Austin Central

Austin, Texas, 78731, United States
Universitaetsklinikum Jena

Jena, Thuringia, 07747, Germany
University of California, San Francisco (UCSF)

San Francisco, California, 94143, United States
Uniwersyteckie Centrum Kliniczne, Klinika Hematologii i Transplantologii

Gdansk, Pomeranian Voivodeship, 80-952, Poland
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States

Conditions

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ADULT HEMATOLOGIC MALIGNANCIES HEMATOLOGIC MALIGNANCIES