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New study tests if extra nerve block can cut opioid use after knee replacement

NCT ID NCT07526831

Symptom relief Sponsor: TC Erciyes University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two types of nerve blocks for pain relief after total knee replacement. One group gets a standard adductor canal block, while the other gets that block plus an IPACK block. Researchers will measure pain scores and how much morphine patients need in the first 24 hours after surgery. The goal is to see if the combined approach offers better pain control with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nerve block procedure (adductor canal block with or without IPACK block)
What this could lead to
If successful, this could show that adding an IPACK block provides better pain relief and reduces the need for strong painkillers after knee surgery.
What could go wrong
This is a small, early-stage study with only 60 participants. The results may not apply to all patients, and the added block may not provide significant extra benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients aged ≥18 years, classified as ASA physical status I-III, scheduled to undergo total knee arthroplasty.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA (American Society of Anesthesiologists) I- ASA II-ASA III Patients Exclusion Criteria: * history of allergy to the study medication * refusal to participate

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee arthroplasty, total

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sibel Pehlivan

    RECRUITING

    Kayseri, Talas, 38090, Turkey (Türkiye)

  • Sibel Seckin Pehlivan

    RECRUITING

    Kayseri, 38039, Turkey (Türkiye)

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