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New study aims to find best pain relief after knee replacement

NCT ID NCT07267650

Symptom relief Sponsor: Turgutlu State Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at two different methods to control pain after total knee replacement. One method combines two nerve blocks given by an anesthesiologist, while the other uses a nerve block plus a local painkiller injection by the surgeon. Researchers will review the medical records of 100 patients to see which approach leads to less pain during movement 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nerve block (iPACK block) and local anesthetic infiltration
What this could lead to
If successful, this could show that a specific nerve block combination provides better pain control after knee replacement, potentially improving recovery and reducing opioid use.
What could go wrong
This is a small, retrospective study at a single hospital, so results may not apply to all patients. It only looks at past records, not a controlled experiment, so other factors could influence the outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients who underwent elective, primary, unilateral total knee arthroplasty (TKA) under spinal anesthesia at Turgutlu State Hospital. Patient records and institutional registries will be reviewed retrospectively to identify eligible cases managed within a specific operational period (e.g., between December 2025 and May 2026). The cohort includes patients who received either an ultrasound-guided Femoral Triangle Block combined with an iPACK block or a hybrid combination of Femoral Triangle Block and surgeon-administered Periarticular Infiltration for postoperative analgesia as part of standard clinical care.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status II-III. * Scheduled for elective, primary, unilateral total knee arthroplasty for osteoarthritis. * Able to provide written informed consent. Exclusion Criteria: * Patient refusal to participate or contraindication to regional anesthesia. * Known allergy to any study medications (local anesthetics, NSAIDs, tramadol, morphine, paracetamol). * History of chronic opioid use (defined as daily use for \>3 months) * Pre-existing peripheral neuropathy in the operative limb. * Severe renal or hepatic insufficiency. * Cognitive impairment preventing the use of pain scales or questionnaires. * Revision or bilateral knee arthroplasty.

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Conditions

The condition(s) this trial relates to.

agnosia osteoarthritis osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee / osteoarthritis, hip Pain, postoperative

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Turgutlu State Hospital+

    Manisa, Manisa, 45000, Turkey (Türkiye)

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