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Which knee surgery approach gets you back on your feet faster?

NCT ID NCT07742696

Disease control Sponsor: Peking University Third Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial compares two surgical techniques for total knee replacement—the subvastus approach and the medial parapatellar approach—to see which one leads to better recovery and function. The study will enroll 84 people with severe knee osteoarthritis who need a knee replacement. Participants will be randomly assigned to one of the two procedures and followed for two years to measure muscle strength, pain, mobility, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two surgical procedures for total knee replacement: the subvastus approach and the medial parapatellar approach
What this could lead to
If one approach proves better, it could lead to faster recovery, less pain, and improved long-term function for people undergoing knee replacement surgery.
What could go wrong
This is a relatively small study, and results may not apply to all patients. Surgery carries risks like infection, blood clots, and nerve damage, and the benefits of one approach over the other may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 84 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 50 to 80 who are diagnosed with end-stage knee osteoarthritis that require unilateral primary total knee arthroplasty; * Patients who are determined by clinical and laboratory tests to have no absolute surgical contraindications; * Patients with good compliance, willing and able to undergo follow-up observations as required and sign the informed consent form; Exclusion Criteria: * Patients with a history of surgery on the affected knee joint in the past; * Patients with neuromuscular diseases; * Patients scheduled for knee joint replacement revision surgery; * Patients with active knee joint infection or systemic infection; * Patients who receive primary joint replacement due to non-knee osteoarthritis, such as rheumatoid arthritis, tuberculous arthritis, traumatic arthritis, etc; * Patients with valgus or varus deformity of the knee joint greater than 15°; * Patients with knee flexion deformity greater than 15°; * Patients whose heart and lung functions are determined by clinical and laboratory tests to be unable to tolerate surgery; * Patients with mental disorders who are unable to cooperate with treatment; * Patients who is lactating or pregnant; * Patients who are unwilling to participate in this study and did not sign the informed consent form; * Patients with poor compliance and inability to cooperate in completing the follow-up observers at critical times; * For any reason, the researchers believe that the subject is unlikely to complete this study.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis (OA) of the knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Orthopaedic Department of Peking University Third Hospital

    Beijing, Haidian, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.