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Botox vs steroids for knee pain: study pulled before starting

NCT ID NCT03726788

Symptom relief Sponsor: Lille Catholic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This study was designed to see if a Botox injection into the knee joint could relieve arthritis pain better than a steroid injection. Researchers planned to use special MRI scans to measure inflammation. However, the trial was withdrawn before enrolling any participants, so no results are available.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Botulinum toxin type A (Botox) and triamcinolone hexacetonide (corticosteroid)

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Expected to start

Sep 2019

An estimate. Start dates often move.

Expected to finish

Apr 2022

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presenting gonarthrosis of degenerative origin, Kellgren/Lawrence Radiological Stage I to III, with a maturity of more than 18 months * With pain intensity greater than or equal to 50/100 on an VAS * In case of bilateral gonarthrosis, the VAS of the contralateral knee must be less than or equal to 30/100 * Presenting a failure of conventional per os treatments (non-steroidal anti-inflammatory drugs, analgesics) * Affiliated with a social security scheme * For women of childbearing age: * effective contraception for the duration of the study Exclusion Criteria: * Patient presenting at the time of the inclusion visit: an inflammatory attack, septic or inflammatory arthritis, a generalized infectious episode in progress * Local or regional local skin lesion * Need of an arthroplasty within the next 12 months * Having received corticosteroids or other molecules in intra-articular infiltration in the last 6 months * History of traumatic knee injury (bone injury in the past 24 months), bone, ligament or meniscal surgery in the past 24 months * History of disabling peripheral nerve injury * Severe bleeding disorders, anticoagulant treatment in progress or double antiplatelet aggregation * BMI \> 35 kg/m2 * Coxarthrosis with projected knee pain * Pregnant or breastfeeding woman * Patient under guardianship and protection of justice * Allergy/contraindication to botulinum toxin type A, corticoids * Usual contraindication to MRI * Allergy to the contrast product

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Conditions

The condition(s) this trial relates to.

arthropathy osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Joint diseases KNEE Magnetic resonance imaging Therapeutics

Contacts and locations

Locations

  • Lille Catholic University

    Lille, 59000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.