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Which knee implant lasts longer? trial pits two designs against each other

NCT ID NCT07818343

Disease control Sponsor: Medstar Health Research Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers compare two knee implant designs used when a previous knee replacement fails and needs revision surgery. Adults under 80 who need both the thigh and shin components replaced join the study. One group receives a rotating hinge knee implant and the other a condylar constrained knee implant. The trial tracks reoperation rates, implant loosening, knee motion, stability, and patient satisfaction over 10 years to see how the two designs compare.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two types of knee implants: a rotating hinge knee and a condylar constrained knee
What this could lead to
If one implant design works better, surgeons could choose it more often for revision knee replacements, potentially reducing the need for further operations.
What could go wrong
Both implants are already used in practice, and this trial may show they perform similarly. Revision knee surgery carries risks of infection, loosening, and stiffness regardless of implant type.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 186 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jan 2037

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion: * Undergoing a revision total knee arthroplasty for any etiology * Requires revision of both tibial and femoral components Exclusion: * Undergoing primary total knee arthroplasty * Candidate for only rotating hinge knee implant * Diagnosed with active infection * Does not meet age criteria of \>18 or \<80 * Pregnant or breastfeeding * Unable to consent * Non-independent dweller (prisoner)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE Revision arthroplasty

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medstar Georgetown University Hospital

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

  • Medstar Montgomery Medical Center

    RECRUITING

    Olney, Maryland, 20832, United States

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