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New study aims to ease Post-Surgery knee pain without opioids

NCT ID NCT07588958

Symptom relief Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two types of nerve blocks—genicular nerve block and adductor canal block—for pain relief after total knee replacement. It involves 42 adults over 65 undergoing elective knee surgery. The goal is to see which block provides better pain control and helps patients recover faster with less opioid use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine and fentanyl (spinal anesthesia); bupivacaine (genicular nerve block)
What this could lead to
If successful, this could point to a better way to manage pain after knee replacement, helping patients move sooner and use fewer opioids.
What could go wrong
This is a small, early-stage trial with only 42 participants, so results may not apply to everyone. Nerve blocks carry risks like infection or temporary weakness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 42 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient acceptance. * Sex: both; male and female. * Age: over 65 years old. * American society of anesthesiologists (ASA): II . * Body mass index (BMI) less than 35 kg/m2. * Operation : elective unilateral TKA. * Duration of surgery : 2-3 hours. Exclusion Criteria: * History of allergy to local anesthetics (lidocaine or bupivicaine). * Coexisting hematologic disorders or malnourished patient. * Pre-existing major organ dysfunction including hepatic or renal failure, and left ventricular ejection fraction \<30% * Peripheral neuropathy. * Patients with a diagnosis of cognitive impairment or significant psychiatric illness. * Skin infection at site of block. * Contraindication to spinal anesthesia as coagulopathy and infection at site of injection.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain after total knee arthroplasty

Contacts and locations

Locations

  • Faculty of Medicine - Zagazig University

    Zagazig, Alsharqia, 4115, Egypt

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