New scaffold implant shows promise for damaged knee cartilage
NCT ID NCT05924763
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a special implant called BiCRI in 11 people with knee cartilage damage. The implant is a scaffold that helps new cartilage grow. Researchers measured pain, knee function, and tissue healing. The goal was to see if the implant is safe and works for tough cases, including failed prior treatments.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Biphasic Cartilage Repair Implant (BiCRI) - a two-phase scaffold made of PLGA and β-TCP
- What this could lead to
- If successful, this implant could offer a new way to repair knee cartilage damage, potentially reducing pain and improving knee function.
- What could go wrong
- This was a very small study (11 people) with no comparison group, so results may not apply to everyone. The implant is still experimental and long-term benefits are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
11 people
The number who actually took part.
- Started
-
May 2019
- Finished
-
Aug 2022
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
16 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. \- Age between 16\~65 (inclusive) years old presenting with either symptomatic chondral or osteochondral lesion of knee requiring primary surgical intervention. The lesions may include but not limited to following conditions: * multiple lesions * lesion that had been treated with microfracture or mosaicplasty but failed. 2. The index lesion is ICRS grade 3-4 lesion, Outerbridge grade 4, or OCD grades 3-4 3. Willing and able to consent in wiring to participate in the study Exclusion Criteria: * 1\. Rheumatoid arthritis and other inflammatory arthritis 2. The index cartilage lesion requires more than 3 (exclusive) implants 3. Skeletally immature (epiphyses are not closed based on x-ray) 4. Concomitant comorbidities 5. Local or systemic infection, not including asymptomatic urinary tract infection if treated with antibiotics preoperatively 6. Pregnancy or breast feeding 7. Prisoner 8. Patient is actively participating in another medical device, drug, or biologic investigation (active defines as within the last 30 days prior to signing the consent form) 9. Any condition that is not suitable to participate in the study based on the physician's judgement
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Articular cartilage disorder of knee are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
En Chu Kong Hospital
New Taipei City, Taiwan
-
Ministry of Health and Welfare Shuang-Ho Hospital
New Taipei City, Taiwan
More trials for these conditions
Other studies related to the condition(s) this trial covers.