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Ketone drink tested for kidney and blood pressure benefits in hypertension

NCT ID NCT06418074

Knowledge-focused Sponsor: Gødstrup Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a special ketone drink (KE4) could improve kidney function and lower blood pressure in 20 people with essential hypertension. Participants took the drink or a placebo for five days, then switched after a break. The goal was to see changes in blood pressure, kidney blood flow, and sodium handling. This is a small, early-stage trial meant to gather information, not to prove a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketone monoester (KE4) drink
What this could lead to
If successful, this could point toward a new dietary approach to help manage blood pressure and protect kidney function in people with hypertension.
What could go wrong
This is a very small, early-stage trial with only 20 participants. The results may not apply to everyone, and the ketone drink might cause side effects like stomach upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Sep 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Essential hypertension (treatment with maximum 2 antihypertensive drugs) * eGFR \> 60ml/min * BMI \< 35 kg/m2 * Urine Albumin Creatinin Ratio (UACR) \< 300mg/g * Safe contraception if women in childbearing age Exclusion Criteria: * Diabetes type 1 or 2 * Heart Failure * Pregnancy or breast feeding * Liver disease * Malignant disease * Recent acute myocardial infarction (AMI), apoplexia/transient ischemic attack (TIA) (within 12 months of inclusion) * Daily use of prescription drugs (expect for contraceptives) * Alcohol or drug abuse * Periodic fasting * Routinely intake of ketogenic diet * Treatment with immunosuppressants or SGLT2-inhibitors

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Conditions

The condition(s) this trial relates to.

essential hypertension Ketosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Essential hypertension Ketosis

Contacts and locations

Locations

  • The University Clinic in Nephrology and Hypertension, Gødstrup Region Hospital

    Herning, 7400, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.