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Diet showdown: can keto or mediterranean ease psoriasis and joint pain?

NCT ID NCT06164860

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether an 8-week ketogenic or Mediterranean diet could reduce inflammation in 26 adults with obesity, psoriasis, and psoriatic arthritis. Participants followed one of the two diets, and researchers measured skin severity (PASI score) and joint activity (DAPSA score), along with inflammatory markers like IL-6 and IL-17. The goal was to see if diet alone could improve symptoms beyond standard medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dietary intervention (ketogenic diet or Mediterranean diet)
What this could lead to
If successful, this could show that a specific diet helps reduce skin and joint inflammation in people with obesity and psoriatic arthritis.
What could go wrong
This is a small, completed trial with only 26 participants, so results may not apply to everyone. Dietary changes can be hard to maintain long-term.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

26 people

The number who actually took part.

Started

May 2020

Finished

Aug 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. age above 18 years 2. body mass index (BMI) \>30 kg/m2 3. diagnosis of psoriasis and psoriatic arthritis under constant systematic treatment with biologic agents and/or synthetic disease-modifying anti-rheumatic drugs (DMARDs) for at least 3 months. 4. ΔPASI SCORE\<75, with moderate or severe activity in joints ( \> 3 swollen \&\> 3 tender joints ή DAPSA\< 14). Exclusion Criteria: 1. participation in another study 2. eGFR\<60ml/min/1.73m2 3. malignancy 4. severe hepatic disorder 5. HbA1C\>10% 6. use of glucagon-like-petide-1 analogues

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Vaia Lambadiari

    Athens, Attica, 12462, Greece

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