Diet showdown: can keto or mediterranean ease psoriasis and joint pain?
NCT ID NCT06164860
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether an 8-week ketogenic or Mediterranean diet could reduce inflammation in 26 adults with obesity, psoriasis, and psoriatic arthritis. Participants followed one of the two diets, and researchers measured skin severity (PASI score) and joint activity (DAPSA score), along with inflammatory markers like IL-6 and IL-17. The goal was to see if diet alone could improve symptoms beyond standard medication.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Dietary intervention (ketogenic diet or Mediterranean diet)
- What this could lead to
- If successful, this could show that a specific diet helps reduce skin and joint inflammation in people with obesity and psoriatic arthritis.
- What could go wrong
- This is a small, completed trial with only 26 participants, so results may not apply to everyone. Dietary changes can be hard to maintain long-term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
26 people
The number who actually took part.
- Started
-
May 2020
- Finished
-
Aug 2023
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 75 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. age above 18 years 2. body mass index (BMI) \>30 kg/m2 3. diagnosis of psoriasis and psoriatic arthritis under constant systematic treatment with biologic agents and/or synthetic disease-modifying anti-rheumatic drugs (DMARDs) for at least 3 months. 4. ΔPASI SCORE\<75, with moderate or severe activity in joints ( \> 3 swollen \&\> 3 tender joints ή DAPSA\< 14). Exclusion Criteria: 1. participation in another study 2. eGFR\<60ml/min/1.73m2 3. malignancy 4. severe hepatic disorder 5. HbA1C\>10% 6. use of glucagon-like-petide-1 analogues
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Obesity are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Vaia Lambadiari
Athens, Attica, 12462, Greece
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Custom knee guides put to the test in obese patients
- A pill for obesity? early human trial puts MDR-001 to the test
- Can a weekly shot help people who still struggle with weight after bariatric surgery?
- Do GLP-1 Weight-Loss drugs change how teens eat and feel?
- Can electrical muscle stimulation boost exercise benefits after menopause?
- Can a cold cloth on the neck calm Post-Surgery nausea?