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Could a High-Fat diet help tame eating disorder thoughts?

NCT ID NCT06000774

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a therapeutic ketogenic diet can reduce troubling eating disorder symptoms like the drive to restrict, binge, or purge, and body dissatisfaction. It includes adults with anorexia nervosa (both weight-recovered and underweight) and bulimia nervosa. Over 14 weeks, researchers will monitor safety, mood, and changes in eating disorder behaviors.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
therapeutic ketogenic diet
What this could lead to
If it works, this could point toward a dietary approach to help manage persistent eating disorder thoughts and behaviors.
What could go wrong
This is a very small early study with only 20 participants, so results may not apply widely. The diet may be hard to follow or cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Weight-Recovered AN Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Persons, aged 18 to 45 years 4. History of anorexia nervosa according to DSM-5 criteria 5. Weight recovered at the time of study inclusion (body mass index \> 17.5 kg/m2) 6. Greater or equal to 2 standard deviations scores of eating disorder-relevant behaviors on the Eating Disorder Inventory-3 and Eating Disorder Examination Questionnaire 7. The following types of psychiatric medications are allowed: antidepressant, anxiolytic, atypical antipsychotic, mood stabilizers 8. English is primary spoken language Weight-Recovered AN Exclusion Criteria: 1. Pregnancy or lactation 2. Electrolyte, blood count, kidney function or liver function abnormalities 3. Psychosis 4. Neurocognitive disorders including dementias or traumatic brain injury that is symptomatic 5. Current alcohol use disorder (AUD) or substance use disorder (SUD) according to DSM-5 criteria 6. Uncontrolled hypertension 7. Hepatic impairment (Class-Pugh b or c) 8. Diabetes mellitus 9. Family history of porphyria 10. History of recent heart attack, vascular disease, or any other current acute medical conditions as determined by the principal investigator 11. Inability or unwillingness to adhere to the TKD diet for the duration of the study 12. Blind or illiterate individuals Underweight AN Sub-Study Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Persons, aged 18 to 45 years 4. Anorexia nervosa according to DSM-5 criteria 5. Current Body Mass Index (BMI) at the time of study inclusion of 16.0 to 17.49 6. An elevated EDE-Q global score of 2.09 or greater 7. The following types of psychiatric medications are allowed: antidepressant, anxiolytic, atypical antipsychotic, mood stabilizers 8. English is primary spoken language Underweight AN Sub-Study Exclusion Criteria: 1. Pregnancy or lactation 2. Electrolyte, blood count, kidney function or liver function abnormalities 3. Psychosis 4. Neurocognitive disorders including dementias or traumatic brain injury that is symptomatic 5. Current alcohol use disorder (AUD) or substance use disorder (SUD) according to DSM-5 criteria 6. Uncontrolled hypertension 7. Hepatic impairment (Class-Pugh b or c) 8. Diabetes mellitus 9. Family history of porphyria 10. History of recent heart attack, vascular disease, or any other current acute medical conditions as determined by the principal investigator 11. Inability or unwillingness to adhere to the TKD diet for the duration of the study 12. Blind or illiterate individuals Bulimia Nervosa Pilot Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Persons, aged 18 to 45 years 4. History of bulimia nervosa according to DSM-5 criteria 5. An elevated EDE-Q global score of 2.09 or greater 6. The following types of psychiatric medications are allowed: antidepressant, anxiolytic, atypical antipsychotic, mood stabilizers 7. English is primary spoken language Bulimia Nervosa Pilot Exclusion Criteria: 1. Pregnancy or lactation 2. Electrolyte, blood count, kidney function or liver function abnormalities 3. Psychosis 4. Neurocognitive disorders including dementias or traumatic brain injury that is symptomatic 5. Current alcohol use disorder (AUD) or substance use disorder (SUD) according to DSM-5 criteria 6. Uncontrolled hypertension 7. Hepatic impairment (Class-Pugh b or c) 8. Diabetes mellitus 9. Family history of porphyria 10. History of recent heart attack, vascular disease, or any other current acute medical conditions as determined by the principal investigator 11. Inability or unwillingness to adhere to the TKD diet for the duration of the study 12. Blind or illiterate individuals

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of California San Diego

    RECRUITING

    San Diego, California, 92121, United States

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