Could a High-Fat diet calm bipolar brain?
NCT ID NCT06221852
First seen Nov 06, 2025 · Last updated Jun 23, 2026 · Updated 28 times
Summary
This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and psychiatric symptoms in people with early bipolar disorder. Fifty participants will follow either the ketogenic diet or standard dietary guidelines for 12 weeks. Researchers will measure changes in brain metabolism, mood, and psychotic symptoms.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Phone: •••-•••-•••• Email: •••••@•••••
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Locations
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McLean Hospital
RECRUITINGBelmont, Massachusetts, 02478, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketogenic diet
What this could lead to
If it works, this could point toward a dietary approach to help manage symptoms in early bipolar disorder.
What could go wrong
This is a small, early-stage trial with only 50 participants. The diet is strict and may be hard to follow, and results may not apply to everyone with bipolar disorder.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.