Please sign in to follow a disease.
New drug combo may prevent dangerous blood pressure drops during anesthesia in seniors
NCT ID NCT07002073
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two different drug mixtures—Ketodex and Ketofol—to see which one causes fewer dangerous drops in blood pressure when putting elderly patients (over 65) to sleep for surgery. 102 participants having non-cardiac surgery were randomly assigned to receive one of the two mixtures. The main goal was to measure how often blood pressure fell too low from the start of anesthesia until 16 minutes after breathing tube placement.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ketamine-dexmedetomidine (Ketodex) and propofol-ketamine (Ketofol) drug mixtures
- What this could lead to
- If one mixture causes fewer dangerous drops in blood pressure, it could become a safer way to put elderly patients to sleep for surgery.
- What could go wrong
- This is a small, completed study with only 102 participants, so results may not apply to all elderly patients or surgeries. The drugs themselves can still cause side effects like low blood pressure or slow heart rate.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
102 people
The number who actually took part.
- Started
-
Apr 2025
- Finished
-
Feb 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
65 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Elderly patients (\>65 years) * ASA physical status I-III * Elective non-cardiac surgery under general anesthesia. Exclusion Criteria: * Patients with severe cardiac morbidities (impaired contractility with ejection fraction \< 50%, heart block, arrhythmias, tight valvular lesions, metabolic equivalent \[MET\] less than 4 * Patients on angiotensin-converting enzyme inhibitors and angiotensin receptor blockers medications * Patients with uncontrolled hypertension * patients undergoing adrenalectomy * patients with body mass index \<18 or \> 35 kg/m² * patient with allergy to any of the study drugs. * patient is considered to be a difficult intubation in the preoperative assessment.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Ketamine-dexmedetomidine induction of anesthesia are added.
Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cairo University Hospitals
Cairo, Giza Governorate, Egypt