Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a ketamine cocktail cut opioid use after spine surgery?

NCT ID NCT07452705

Symptom relief Sponsor: University of Malaya Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding low-dose ketamine to standard morphine pain pumps helps teens use less morphine after scoliosis surgery. About 114 patients aged 10-18 will be randomly assigned to get either the combo or morphine alone. The goal is to see if the combo reduces opioid use and side effects while keeping pain under control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ketamine and Morphine (combined in a patient-controlled pump)
What this could lead to
If it works, this could offer a safer way to manage pain after scoliosis surgery, reducing opioid use and side effects like nausea or drowsiness.
What could go wrong
This is a small, early-phase trial (114 participants) that hasn't started yet. The benefit may be small or not apply to all patients, and ketamine can cause side effects like hallucinations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 114 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: 1. Aged \> 10 years old 2. Idiopathic scoliosis scheduled for single-stage posterior spinal fusion (PSF). 3. American Society of Anaesthesiologists (ASA) physical status I-II. Exclusion criteria: 1. Known hypersensitivity to morphine, ketamine or formulation excipients. 2. Hepatic dysfunction (ALT or AST \> 2 × upper limit of normal). 3. Renal impairment (eGFR ≤ 60 mL min-¹ 1·73 m-²). 4. Uncontrolled asthma or severe restrictive lung disease. 5. Cardiac disease or clinically significant arrhythmia. 6. Epilepsy. 7. Intellectual disability precluding PCA use. 8. Chronic opioid therapy or pre-operative pain \> 3 months. 9. Concomitant monoamine-oxidase inhibitor or tricyclic antidepressant therapy. 10. History of severe postoperative delirium.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Adolescent idiopathic scoliosis (AIS) are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

adolescent idiopathic scoliosis agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adolescent idiopathic scoliosis (AIS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Malaya Medical Centre

    Kuala Lumpur, Kuala Lumpur, 59100, Malaysia

More trials for these conditions

Other studies related to the condition(s) this trial covers.