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Can ketamine silence the ringing? new study tests a surprising treatment for tinnitus

NCT ID NCT03336398

Symptom relief Sponsor: New York State Psychiatric Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether ketamine, a drug that blocks certain brain signals, can help people with tinnitus (ringing in the ears). 42 adults with chronic tinnitus received both ketamine and a placebo on different days. Researchers used brain scans to measure changes in brain chemicals linked to tinnitus. The goal was to see if ketamine could reduce tinnitus distress, especially in those who also feel anxious or depressed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

42 people

The number who actually took part.

Started

Sep 2019

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant aged 21-60 * Tinnitus associated with at least mild sensori-neural hearing loss of at least 6 months duration * Score at least 32 on the Tinnitus Handicap Inventory and a score of 5dB or greater on the minimum masking level * Tinnitus not due to medical disease (other than sensorineural hearing loss) * Score of at least 14 on the Hamilton Depression Rating Scales with a score of at least 2 on the Hamilton Anxiety Rating Scale (in the distressed group). Exclusion Criteria: * DSM-V psychiatric disorders other than mild-moderate depression and anxiety, including substance use disorder. * History of recreational ketamine use, recreational PCP use,exposure to ketamine as an anesthetic, or an adverse reaction to ketamine * Currently taking psychotropic medication (e.g.antipsychotics, antidepressants, benzodiazepines) * Presence or positive history of significant medical or neurological illness, including high blood pressure (SBP \>140, DBP \> 90), cardiac illness, abnormality on EKG, head injury. * Pregnancy, abortion, or lack of effective birth control during 15 days before the scan * Metal implants, pacemaker, other metal (e.g. shrapnel or surgical prostheses) or paramagnetic objects contained within the * Medicinal patch that cannot be removed for the scans.

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Conditions

The condition(s) this trial relates to.

tinnitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tinnitus

Contacts and locations

Locations

  • 1051 Riverside Drive

    New York, New York, 10032, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.