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Brain scans track rare childhood Huntington's disease

NCT ID NCT05707663

Knowledge-focused Sponsor: University of Iowa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study follows 37 children and young adults with juvenile-onset Huntington's disease (JoHD) to understand how their brains develop differently from adult-onset cases. Participants undergo cognitive tests, behavioral assessments, and MRI scans over time. The goal is to find reliable brain-based markers that could help monitor the disease in future research.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could identify reliable brain-based biomarkers for juvenile Huntington's disease, helping future research track disease progression more accurately.
What could go wrong
This is a small observational study (37 participants) that does not test any treatment. It may not yield clear biomarkers due to the rarity and variability of juvenile-onset HD.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

37 people

The number who actually took part.

Started

Jan 2020

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Children, adolescents and young adults ages 4-30 who have been clinically diagnosed with Juvenile-onset Huntington's Disease

Ages

4 to 30 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of JoHD * Aged 4-30 Exclusion Criteria: * Metal in body * History of head trauma, brain tumor, seizures or epilepsy unrelated to JoHD * History of major surgery or serious chronic medical conditions other than JoHD

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Conditions

The condition(s) this trial relates to.

Huntington disease juvenile Huntington disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Juvenile Huntington disease Juvenile-onset Huntington disease

Contacts and locations

Locations

  • Children's Hospital of Philadelphia with the University of Pennsylvania

    Philadelphia, Pennsylvania, 19146, United States

  • University of California Davis

    Sacramento, California, 95817, United States

  • University of Iowa Hospitals and Clinics, Department of Psychiatry

    Iowa City, Iowa, 52242, United States

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States