JointIQ supplement shows promise for active adults with knee discomfort
NCT ID NCT07382622
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a daily supplement called JointIQ (made from astragaloside) can reduce knee discomfort and improve mobility in healthy, active adults. Fifty participants took either the supplement or a placebo for 12 weeks. The goal was to see if those taking JointIQ had better knee stability, range of motion, and fewer symptoms.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Oct 2024
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy male or female adults, aged 18 to 75 years, with a body mass index (BMI) of 18-30 kg/m². * Actively participates in regular exercise, including but not limited to soccer, basketball, tennis, rugby, running, or cycling, and engages in at least two training sessions per week during the study period. * Experiences pain ≥5 on a Visual Analog Scale (VAS) during the Single-Leg Step-Down (SLSD) test when performing 30 to 150 steps. * Has experienced knee discomfort within the last 3 months during or after physical activity. Exclusion Criteria: * Participation in another clinical trial within 30 days prior to study enrollment. * Uncontrolled diabetes or currently using insulin therapy. * Current smokers. * History of heart failure. * Previous bilateral knee replacement surgery. * Current use of prescription COX-2 inhibitors, chondroitin sulfate, glucosamine sulfate or hydrochloride, collagen, fish oil, or vitamin D supplements and unwilling to discontinue these during the study. * Likely to be lost to follow-up, non-compliant, or requiring concomitant medication that may interfere with study outcomes. * Received intra-articular treatment within 3 months prior to study start. * Medical conditions that may interfere with study results, such as cancer, cardiovascular disease (e.g., stroke, myocardial infarction), pregnancy, or breastfeeding. * Hip, spine, or foot injuries that could affect study outcomes.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chung Shan Medical University
Taichung, 402, Taiwan
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