New NASH pill tested in humans for first time
NCT ID NCT06308861
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tested a new oral drug called J2H-1702 in 100 healthy men to see if it is safe and how the body processes it. The drug is being developed for non-alcoholic steatohepatitis (NASH), a type of liver disease. The study was completed and used a placebo for comparison.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- J2H-1702 (oral tablet)
- What this could lead to
- If successful, this could lead to a new oral treatment option for non-alcoholic steatohepatitis (NASH), a serious liver disease.
- What could go wrong
- This is a very early Phase 1 trial in only 100 healthy men, not patients. It primarily checks safety, not whether the drug works for NASH. Many drugs fail at this stage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
100 people
The number who actually took part.
- Started
-
Aug 2020
- Finished
-
Jul 2021
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
19 to 45 years
- Sex
-
Male participants only
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. A healthy male adult within the range of 19 to 45 years old 2. BMI=18.0\~27.0kg/m2 (Body mass index, BMI) 3. A subject confirmed to be clinically healthy based on the medical history, physical examination, vitals signs, ECG, and appropriate clinical laboratory tests 4. A subject who his spouse or partner agrees to use dual contraceptive methods and not to donate sperms 5. A subject who has voluntarily agree to participate in the study Exclusion Criteria: 1. A subject who had or has the disease corresponding to clinically significant liver, etc. 2. A subject with a history of gastrointestinal diseases or surgery 3. A subject who has a history of clinically significant hypersensitivity to drugs containing 11β-HSD1 inhibitor 4. A subject who has genetic problems such as galactose intolerance, Lap galactose intolerance, Lap lactase deficiencies, or glucose ∙galactose malabsorptivity, etc. 5. One who has drug abuse and one who is positive response in urine drug screening tests 6. A subject with abnormal vital signs at the screening visit 7. A subject who has participated in another clinical trial or bioequivalence test 8. A subject who donated whole blood or the ingredient, or received blood transfusion 9. A subject who took drug metabolizing enzyme-inducing and inhibitory drugs 10. A subject who consumes grapefruit/caffeine-containing food 11. A subject who took any prescription drug or herbal medicine or took any Over The Counter Drug (OTC) 12. High caffeine intaker, high alcohol intaker or excessive smoker 13. A subject who cannot eat meals provided by the Clinical Trial institution. 14. A subject who participated in this trial and were administered the investigational product. 15. A subject who is positive for serum test 16. A subject who the investigator deems inappropriate for this clinical trial.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Non - alcoholic steatohepatitis are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
J2H Biotech
Suwon, Gyeonggi-do, 16684, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new ultrasound device spot liver damage without a biopsy?
- Can we spot cancer before it starts? a massive study aims to find out
- A new MRI technique could see inside the Liver's metabolism without a biopsy
- Blood test and AI could spot liver cancer early, saving lives
- Painless liver check: could a quick scan replace the needle?
- Computer nudge boosts liver referrals