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New drug could shrink nasal polyps and ease breathing

NCT ID NCT06834347

First seen Oct 31, 2025 · Last updated May 24, 2026 · Updated 32 times

Summary

This study tests a drug called itepekimab for adults with chronic sinusitis and nasal polyps that are not well controlled. About 231 participants will receive either the drug or a placebo for 52 weeks, along with standard nasal spray. The goal is to see if itepekimab can shrink polyps and reduce nasal congestion.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • ASST Santi Paolo e Carlo-Presidio Ospedale San Paolo-Site Number : 3800006

    Milan, Milano, 20142, Italy

  • Advanced Research Associates (ARA) Professionals- Site Number : 8400011

    Miami, Florida, 33176, United States

  • Alamo ENT Associates- Site Number : 8400065

    San Antonio, Texas, 78258, United States

  • Azienda Ospedale - Università Padova-Site Number : 3800008

    Padua, Padova, 35128, Italy

  • Azienda Ospedaliera Universitaria Careggi-Site Number : 3800011

    Florence, Firenze, 50134, Italy

  • Azienda Ospedaliero-Universitaria di Ferrara-Site Number: 3800004

    Cona, Ferrara, 44124, Italy

  • Breathe Clear Institute of Sinus and Allergy Relief- Site Number : 8400040

    Torrance, California, 90503, United States

  • Centro Internacional de Pesquisa Clínica (CIPES)- Site Number : 0760005

    São José dos Campos, São Paulo, 12230-001, Brazil

  • Deaconess Clinic Allergy East- Site Number : 8400056

    Evansville, Indiana, 47715, United States

  • ENT Associates of Texas - McKinne- Site Number : 8400062

    McKinney, Texas, 75070, United States

  • Eastern Virginia Medical School (EVMS) Medical Group- Site Number : 8400046

    Norfolk, Virginia, 23510, United States

  • Emory University School of Medicine- Grady Campus- Site Number : 8400047

    Atlanta, Georgia, 30303, United States

  • Essential Medical Research- Site Number : 8400066

    Tulsa, Oklahoma, 74137, United States

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Site Number: 3800002

    Rome, Roma, 00168, Italy

  • Hospital Israelita Albert Einstein- Site Number : 0760001

    São Paulo, 05651-901, Brazil

  • Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto- Site Number : 0760002

    Ribeirão Preto, São Paulo, 14049-900, Brazil

  • Houston Methodist Hospital- Site Number : 8400054

    Houston, Texas, 77030, United States

  • IRCCS Ospedale Policlinico San Martino-Site Number : 3800013

    Genoa, Genova, 16132, Italy

  • Investigational Site Number : 0320001

    Buenos Aires, 1425, Argentina

  • Investigational Site Number : 0320002

    La Plata, Buenos Aires, 1900, Argentina

  • Investigational Site Number : 0320003

    Mendoza, 5500, Argentina

  • Investigational Site Number : 0320004

    Rosario, Santa Fe Province, 2000, Argentina

  • Investigational Site Number : 0320005

    Buenos Aires, 1638, Argentina

  • Investigational Site Number : 0400001

    Vienna, 1090, Austria

  • Investigational Site Number : 0400002

    Linz, 4010, Austria

  • Investigational Site Number : 0400005

    Graz, 8036, Austria

  • Investigational Site Number : 1240001

    Québec, Quebec, G1V 4G5, Canada

  • Investigational Site Number : 1240002

    Montreal, Quebec, H4a 3j1, Canada

  • Investigational Site Number : 1240005

    London, Ontario, N6A 4V2, Canada

  • Investigational Site Number : 1520001

    Santiago, Reg Metropolitana de Santiago, 8207257, Chile

  • Investigational Site Number : 1520002

    Santiago, Reg Metropolitana de Santiago, 7500692, Chile

  • Investigational Site Number : 1520003

    Talca, Maule Region, 3465584, Chile

  • Investigational Site Number : 1520004

    Lo Barnechea, Reg Metropolitana de Santiago, 7691236, Chile

  • Investigational Site Number : 1520005

    Viña del Mar, Valparaiso, 2540364, Chile

  • Investigational Site Number : 1520006

    Valdivia, Los Ríos Region, 5110683, Chile

  • Investigational Site Number : 2460002

    Kuopio, 70210, Finland

  • Investigational Site Number : 2460003

    Helsinki, 00130, Finland

  • Investigational Site Number : 2460004

    Helsinki, 00029, Finland

  • Investigational Site Number : 2760001

    Tübingen, 72076, Germany

  • Investigational Site Number : 2760002

    Münster, 48149, Germany

  • Investigational Site Number : 2760003

    Würzburg, 97080, Germany

  • Investigational Site Number : 2760004

    Berlin, 10117, Germany

  • Investigational Site Number : 2760005

    Wiesbaden, 65205, Germany

  • Investigational Site Number : 2760007

    Frankfurt, 60318, Germany

  • Investigational Site Number : 2760008

    Hamburg, 22523, Germany

  • Investigational Site Number : 2760009

    Landsberg, 06188, Germany

  • Investigational Site Number : 3480001

    Pécs, 7621, Hungary

  • Investigational Site Number : 3480002

    Budapest, 1046, Hungary

  • Investigational Site Number : 3480003

    Nyíregyháza, 4400, Hungary

  • Investigational Site Number : 3480004

    Debrecen, 4032, Hungary

  • Investigational Site Number : 3760004

    Kefar Sava, 4428164, Israel

  • Investigational Site Number : 3760005

    Petah Tikva, 4941492, Israel

  • Investigational Site Number : 3760007

    Haifa, 3436212, Israel

  • Investigational Site Number : 3760009

    Tel Aviv, 6423906, Israel

  • Investigational Site Number : 3920001

    Fukuoka, 812-0053, Japan

  • Investigational Site Number : 3920002

    Odawara, Kanagawa, 250-8558, Japan

  • Investigational Site Number : 3920003

    Kumamoto, 860-0814, Japan

  • Investigational Site Number : 3920004

    Narita, Chiba, 286-8520, Japan

  • Investigational Site Number : 3920005

    Suwa, Nagano, 392-0027, Japan

  • Investigational Site Number : 3920006

    Fukui, 910-1104, Japan

  • Investigational Site Number : 3920008

    Tokyo, 153-8515, Japan

  • Investigational Site Number : 3920009

    Isehara, Kanagawa, 259-1193, Japan

  • Investigational Site Number : 3920010

    Ichikawa, Chiba, 272-0143, Japan

  • Investigational Site Number : 3920011

    Hiroshima, 734-0004, Japan

  • Investigational Site Number : 3920012

    Kusatsu, Shiga, 525-0066, Japan

  • Investigational Site Number : 3920013

    Niigata, 951-8520, Japan

  • Investigational Site Number : 3920014

    Yokohama, Kanagawa, 236-0037, Japan

  • Investigational Site Number : 4100001

    Seoul, Seoul-teukbyeolsi, 07061, South Korea

  • Investigational Site Number : 4100002

    Seoul, Seoul-teukbyeolsi, 06351, South Korea

  • Investigational Site Number : 4100003

    Seoul, Seoul-teukbyeolsi, 03080, South Korea

  • Investigational Site Number : 4100004

    Seoul, Seoul-teukbyeolsi, 03722, South Korea

  • Investigational Site Number : 4100005

    Cheonan-Si, Chungcheongnam-do, 31116, South Korea

  • Investigational Site Number : 4100006

    Seoul, 02841, South Korea

  • Investigational Site Number : 4100008

    Incheon, Incheon-gwangyeoksi, 21565, South Korea

  • Investigational Site Number : 4100009

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Investigational Site Number : 4840003

    Durango, 34000, Mexico

  • Investigational Site Number : 4840004

    Chihuahua City, 31000, Mexico

  • Investigational Site Number : 5280002

    Leiderdorp, 2353 GA, Netherlands

  • Investigational Site Number : 5280004

    Alkmaar, 1815 JD, Netherlands

  • Investigational Site Number : 6160001

    Wroclaw, Lower Silesian Voivodeship, 53-149, Poland

  • Investigational Site Number : 6160002

    Warsaw, Masovian Voivodeship, 00-909, Poland

  • Investigational Site Number : 6160003

    Bialystok, Podlaskie Voivodeship, 15-756, Poland

  • Investigational Site Number : 6160004

    Wroclaw, Lower Silesian Voivodeship, 53-301, Poland

  • Investigational Site Number : 6160005

    Lublin, Lublin Voivodeship, 20-363, Poland

  • Investigational Site Number : 6160006

    Krakow, Lesser Poland Voivodeship, 31-513, Poland

  • Investigational Site Number : 6200001

    Santa Maria da Feira, 4520-211, Portugal

  • Investigational Site Number : 6200002

    Porto, 3814-501, Portugal

  • Investigational Site Number : 6200003

    Guimarães, 4800-055, Portugal

  • Investigational Site Number : 6200004

    Matosinhos Municipality, 4464-513, Portugal

  • Investigational Site Number : 7240001

    Majadahonda, Madrid, 28222, Spain

  • Investigational Site Number : 7240002

    Barcelona, Catalunya [Cataluña], 08036, Spain

  • Investigational Site Number : 7240003

    Santiago de Compostela, A Coruña [La Coruña], 15706, Spain

  • Investigational Site Number : 7240004

    Jerez de la Frontera, Cádiz, 11407, Spain

  • Investigational Site Number : 7240005

    Zaragoza, 50009, Spain

  • Investigational Site Number : 7240006

    Seville, Sevilla, 41009, Spain

  • Investigational Site Number : 7240007

    Santiago de Compostela, A Coruña [La Coruña], 15702, Spain

  • Investigational Site Number : 7240008

    Barcelona, Barcelona [Barcelona], 08022, Spain

  • Investigational Site Number : 7240009

    Sabadell, 08208, Spain

  • Investigational Site Number : 7520001

    Solna, 171 64, Sweden

  • Investigational Site Number : 7520002

    Lund, 221 85, Sweden

  • Investigational Site Number : 7520004

    Stockholm, 114 86, Sweden

  • Investigational Site Number : 7920001

    Istanbul, 34093, Turkey (Türkiye)

  • Investigational Site Number : 7920002

    Istanbul, 34865, Turkey (Türkiye)

  • Investigational Site Number : 7920003

    Ankara, 06230, Turkey (Türkiye)

  • Investigational Site Number : 8260001

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • Investigational Site Number : 8260002

    London, London, City of, NW1 2BU, United Kingdom

  • Investigational Site Number : 8260004

    Bradford, BD9 6RJ, United Kingdom

  • Investigational Site Number : 8260006

    Oxford, Oxfordshire, OX3 9DU, United Kingdom

  • Newport Native MD- Site Number : 8400031

    Newport Beach, California, 92663, United States

  • Northwell Health Physician Partners Rheumatology at Great Neck- Site Number : 8400028

    Great Neck, New York, 11021, United States

  • Orlando ENT Associates - Orlando- Site Number : 8400008

    Orlando, Florida, 32807, United States

  • Orso Health - Torrance - Hawthorne Boulevard- Site Number : 8400035

    Torrance, California, 90505, United States

  • Ospedale Bellaria-Site Number: 3800009

    Bologna, 40139, Italy

  • Paradisus Med Research - Miami- Site Number : 8400009

    Miami, Florida, 33185, United States

  • SSM Health Saint Louis University Hospital- Site Number : 8400005

    St Louis, Missouri, 63104, United States

  • Sacramento Ear Nose & Throat - Roseville- Site Number : 8400064

    Roseville, California, 95661, United States

  • Sensa Health- Site Number : 8400038

    Los Angeles, California, 90006, United States

  • TEN20 Clinical Research - Dallas- Site Number : 8400015

    Dallas, Texas, 75244, United States

  • Treasure Valley Medical Research- Site Number : 8400063

    Boise, Idaho, 83706, United States

  • University of Chicago Medical Center- Site Number : 8400018

    Chicago, Illinois, 60637, United States

  • University of Southern California (USC) / Keck Medicine of USC- Site Number : 8400037

    Arcadia, California, 91006, United States

Conditions

Explore the condition pages connected to this study.