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Which anesthetic is gentler on the body? new study aims to find out

NCT ID NCT07152912

Knowledge-focused Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compares two widely used inhaled anesthetics, isoflurane and sevoflurane, to see which one causes less oxidative stress (a type of cell damage) in patients having gallbladder removal surgery. Researchers will measure stress markers in the blood of 80 healthy adults. The goal is to understand if one anesthetic is safer for routine surgeries.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Isoflurane and sevoflurane (inhalation anesthetics)
What this could lead to
If it works, this could help doctors choose the safer anesthetic for surgery, potentially reducing cell damage and inflammation.
What could go wrong
This is a small, early-stage study focused on lab markers, not patient outcomes. The results may not change practice or apply to other surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age from 20 to 60 years. * Both sexes. * American Society of Anesthesiologists (ASA) Physical Status I-II. * Undergoing elective laparoscopic cholecystectomy under general anesthesia. Exclusion Criteria: * Refusal of participation in the study by patients. * Diabetes (type I or II), endocrine system, and immune system diseases. * Chronic infection and sepsis. * Cardiac condition as classified bythe New York Heart Association (NYHA) \> class II. * Hepatic disease: INR \> 1.5, and/or albumin \< 2.5 g/dL. * Renal disease: glomerular filtration rate (GFR) \< 85 ml/min. * Mental and neurological disorders.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Isoflurane Laparoscopic cholecystectomy Oxidative stress Sevoflurane

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ain Shams University

    RECRUITING

    Cairo, 11591, Egypt

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