Can stem cell vesicles help rebuild brain blood vessels in moyamoya?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: 1. Diagnosed adult patients with MMD aged 18-75 years (inclusive), with bilateral terminal occlusion of the internal carotid arteries (ICA) and stenosis or occlusion of the anterior cerebral artery (ACA) and middle cerebral artery (MCA) at the origin, accompanied by the formation of abnormal vascular networks at the base of the skull, as indicated by head DSA or MRA. Unilateral or bilateral lesions are acceptable. Suzuki score ≥ 3. 2. Relevant bone marrow, liver, kidney, and heart function indicators meet the following standards (based on the normal values of the clinical trial center): absolute neutrophil count (ANC) ≥ 1.5×109/L, platelets ≥ 100×109/L, total serum bilirubin ≤ 1.5 times the upper limit of normal (ULN), ALT, AST, or ALP ≤ 3 times ULN; serum creatinine ≤ 1.5 times ULN, international normalized ratio (INR) ≤ 1.5 times ULN, APTT ≤ 1.5 times ULN. 3. Patients have undergone temporal muscle patch surgery and have not achieved satisfactory improvement in symptoms. 4. Patients have been followed up for ≥ 3 months since the surgery. 5. Vascular DSA performed 3 months after the surgery indicates poor blood flow reconstruction. 6. CTP or ASL performed 3 months after the surgery shows ischemia. 7. Patients still have clinical manifestations of cerebral ischemia or cerebral infarction due to MMD 3 months after the surgery. 8. Patients or their legal representatives have given informed consent and signed the informed consent form. Exclusion criteria: 1. Patients with severe liver or kidney dysfunction or other complications; 2. Patients with a history of mental disorders or mental diseases; 3. Patients with coagulation disorders; 4. Patients with extensive cerebral infarction or in a coma; 5. Patients who only undergo direct bypass surgery; 6. Patients who have not signed the surgical consent form; 7. Patients with allergic constitutions or a clear history of allergies; 8. Pregnant women, lactating women, and patients with plans to conceive during the trial period; 9. Patients who have participated in other clinical trials in the past three months; 10. Patients deemed unsuitable for the trial by the researcher.