Bone injection may boost antibiotic power in knee surgery
NCT ID NCT07283068
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving the antibiotic vancomycin directly into the bone (via the ankle) works better than the usual IV method during revision knee replacement surgery. Forty adults having a second knee replacement will be randomly assigned to one of the two methods. Researchers will measure antibiotic levels in the bone and blood to see which route provides higher concentrations where it matters most.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- vancomycin
- What this could lead to
- If this works, it could show that injecting antibiotics directly into the bone is better at preventing infection during knee replacement surgery.
- What could go wrong
- This is a very small, early study with only 40 people. It measures antibiotic levels, not actual infection rates, so it may not lead to better outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient is undergoing a revision total knee arthroplasty where in the opinion of the investigator, the patient's existing tibial component excludes the tibial tubercle as a valid intraosseous injection site. * Patient is able to understand the study design and intervention and gives informed consent to participate in the study. * Age \> 18 years. Exclusion Criteria: * Contraindication to receiving vancomycin, cefepime, ancef, or other standard of care pre-operative antibiotic (allergy, medical issue, etc). * Patient received or is scheduled to receive intravenous Vancomycin within 7 days prior to their planned revision procedure. * Any hardware, condition, or anatomic status that prevents the medial malleolus from being a viable intraosseous injection site. * Refusal to participate * Any condition, in the opinion of the primary investigator, that deems the participant unsuitable for participation in the research study.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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