New test could spot transplant rejection without a biopsy
NCT ID NCT01140152
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether proteins in ostomy fluid (waste from the intestine) can signal rejection after an intestinal transplant. Currently, doctors must take tissue samples through a scope to check for rejection, which is invasive and not always accurate. Researchers analyzed fluid from 17 transplant patients to find protein patterns linked to rejection, hoping to develop a simpler monitoring method.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a simple, non-invasive test to detect rejection early after intestinal transplant.
- What could go wrong
- This is a very small, early study with only 17 participants. The findings may not apply to all patients or lead to a reliable test.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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17 people
The number who actually took part.
- Start date
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Jul 2008
- Finished
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Sep 2009
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All Intestinal transplant recipients at UCLA, who are up to 8 weeks status-post transplant and are undergoing surveillance endoscopy or who present with elevated stool outputs with concern for acute rejection. Controls will consist of all primary ITx recipients of the same follow-up criteria who are undergoing surveillance biopsies but are at their baseline ostomy outputs.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Intestinal transplant recipient * Less than 8 weeks post transplant Exclusion Criteria: * Intestinal transplant recipients more than 8 weeks post transplant
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UCLA
Los Angeles, California, 90095, United States