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Can lack of oxygen weaken your breathing muscles? new study investigates

NCT ID NCT06714435

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether repeated low oxygen levels, like those seen in sleep apnea, can reduce the ability to keep breathing during effort. 28 healthy volunteers did a breathing test after 6 hours of normal air and after 6 hours of low oxygen. The goal is to understand if oxygen drops alone affect breathing endurance, which could help manage asthma attacks or respiratory infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

28 people

The number who actually took part.

Started

Jan 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Non-excessive coffee drinker (\< 3 espressos / day) * Non-smoker or weaned for 3 months and total consumption \< 10 packs/year * With a BMI within \]18 - 25\[ kg/m². * Benefiting from a Social Security plan or benefiting from one through a third party * Giving free, informed and signed consent, after receiving clear and fair information about the study. Non-inclusion Criteria: * History of respiratory or ENT disease (asthma, chronic bronchitis, COPD, respiratory allergy, swallowing disorders, oropharyngeal malformation, obstructive or central sleep apnea-hypopnea syndrome, alveolar hypoventilation syndrome) * Respiratory, cardiovascular, muscular, neurological or diabetic pathology or disorders * Raynaud's disease/syndrome * History of epilepsy or history of malaise suggestive of epilepsy * Psychiatric history requiring hospitalization * Liver failure * Renal insufficiency * History of acute mountain sickness (presence during or after a stay at altitude of symptoms of vertigo, headache, nausea/vomiting and incapacitating fatigue: Lake Louise score \> 0) * History of migraines * Taking medications that interfere with respiratory function or cardiovascular function, or psychotropic drugs ( anxiolytic, sedative, antidepressant, neuroleptic, muscle relaxant, etc.). * Alcohol or drug dependence * Anemia, sickle-cell anemia * SpO2 \< 97% at rest in room air * Currently participating in another clinical study * Protected persons within the meaning of article L1121-5 to 8 (persons benefiting from enhanced protection, i.e. minors, persons deprived of their liberty by a judicial or administrative decision, pregnant or breast-feeding women, persons staying in a health or social establishment, adults under legal protection, and patients in emergency situations). - Women with childbearing capacity who do not have effective contraception (hormonal/mechanical: oral, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy). * Incidental finding of acute mountain sickness (Lake Louise score \>0) * Pregnant woman (incidental finding) * Persistence of average sleep time \< 6h * Non-reversible deterioration in volunteer's state of health within study period * Electroencephalogram signal unusable

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU Poitiers

    Poitiers, France, 86000, France

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