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Can insulin help heal gums? a trial puts it to the test

NCT ID NCT07746206

Disease control Sponsor: Doaa Atta Aid Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This trial tests whether applying insulin or hyaluronic acid gel directly into gum pockets, alongside standard deep cleaning, improves healing in people with stage III periodontitis. About 45 adults with gum disease will receive one of the two gels or cleaning alone, and researchers will measure changes in pocket depth, gum attachment, and markers of inflammation. The goal is to see if these topical treatments can boost the effects of non-surgical gum therapy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Insulin gel or hyaluronic acid gel applied directly into gum pockets after deep cleaning
What this could lead to
If it works, this could point toward a simple, affordable way to improve gum healing and reduce pocket depth in people with advanced periodontitis.
What could go wrong
This is a very early, small trial, so results may not hold up in larger studies. Insulin applied to gums could also cause low blood sugar or other local effects, though risks are likely low.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All selected patients are free from systemic illness as evaluated according to dental modification of the Cornell medical index. * Should be diagnosed as having periodontitis. * Not received any type of periodontal treatment in the past 6 months prior to examination. * Should be cooperative, motivated, and willing to follow our treatment protocol and follow up visits. * Not received antibiotics or anti-inflammatory therapy in the 6 months prior to examination. Exclusion Criteria: * Antibiotic therapy in the preceding 6 months or during study participation. * History of insulin dependent diabetes and thyroid disease. * Pregnancy, smoking, chronic diseases such as diabetes mellitus or rheumatoid arthritis, and allergy to ingredients in the drug. * Poor oral hygiene compliance or inability to adhere to the clinical protocol.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Local application of insulin in pockets Treatment of stage III periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Alazhar university

    RECRUITING

    Cairo, Egypt

  • Faculty of Dental Medicine for Girls, Al-Azhar University

    RECRUITING

    Cairo, Egypt