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Blood-Derived injection may shield teeth from braces damage

NCT ID NCT07352241

Disease control Sponsor: Damascus University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether injecting a substance made from a patient's own blood—called injectable platelet-rich fibrin (i-PRF)—could reduce root shortening that sometimes happens when wearing braces. Thirty-six adults with crowded front teeth received either i-PRF or a saltwater injection during their orthodontic treatment. The goal was to see if i-PRF helps protect the roots of the teeth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
injectable platelet-rich fibrin (i-PRF)
What this could lead to
If it works, this could offer a simple, natural way to protect tooth roots during orthodontic treatment.
What could go wrong
This is a small, early study with only 36 participants, so results may not apply to everyone. The treatment involves injections and may not prevent root damage in all cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Jan 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

17 to 25 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged between 17 and 28 years * Class I malocclusion with moderate crowding (4-6 mm) according to Little's Irregularity Index (LII) * Normal or inclination for mandibular incisors * Complete permanent teeth. Exclusion Criteria: * Previous orthodontic treatment, * Poor oral hygiene, * Severe skeletal discrepancy, * The presence of coagulation disorders or being under anticoagulant treatment.

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Conditions

The condition(s) this trial relates to.

malposition of teeth with or without hypodontia/oligodontia root resorption prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Crowding of anterior maxillary teeth

Contacts and locations

Locations

  • Department of Orthodontics, Faculty of Dentistry, University of Damsacus

    Damascus, DM20 HAJ72, Syria