Breathing in sedation: could a gas help ICU patients leave the ventilator faster?
NCT ID NCT07000526
First seen Jan 05, 2026 · Last updated Jun 22, 2026 · Updated 27 times
Summary
This study tests whether giving sedation as a gas (isoflurane) instead of through an IV (propofol) helps critically ill patients on breathing machines recover faster. About 620 adults in the ICU who need deep sedation will be randomly assigned to one of the two methods. The main goal is to see how many days they are alive and off the ventilator within the first 28 days.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Hospital Arnau de Vilanova
NOT_YET_RECRUITINGLleida, Spain
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Hospital Clínico Universitario de Valencia
RECRUITINGValencia, Spain
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Hospital Galdakao-Usansolo Ospitalea
NOT_YET_RECRUITINGGaldakao, Vizcaya, Spain
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Hospital Germans Trias i Pujol
RECRUITINGBadalona, Spain
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Hospital Regional Universitario de Málaga
NOT_YET_RECRUITINGMálaga, Spain
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Hospital Univeritario Puerta de Hierro
NOT_YET_RECRUITINGMadrid, Spain
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Hospital Universitario Doctor José Molina Orosa
NOT_YET_RECRUITINGArrecife, Lanzarote-Canary Islands, 35500, Spain
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Hospital Universitario Gregorio Marañon
RECRUITINGMadrid, Spain
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Hospital Universitario Infanta Leonor
RECRUITINGMadrid, Spain
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Hospital Universitario Joan XXIII
RECRUITINGTarragona, Spain
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Hospital Universitario La Paz
RECRUITINGMadrid, 28029, Spain
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Hospital Universitario Ramon y Cajal
NOT_YET_RECRUITINGMadrid, 28029, Spain
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Hospital Universitario Rey Juan Carlos
RECRUITINGMadrid, Spain
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Hospital Universitario Rio Hortega
RECRUITINGValladolid, Spain
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Hospital Universitario Valle de Hebron
RECRUITINGBarcelona, Spain
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Hospital Universitario de Albacete
NOT_YET_RECRUITINGAlbacete, Spain
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Hospital Universitario de Bellvitge
RECRUITINGBarcelona, Spain
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Hospital Universitario de Fuenlabrada
NOT_YET_RECRUITINGMadrid, 28029, Spain
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Hospital Universitario de Jaen
NOT_YET_RECRUITINGJaén, Spain
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Hospital Universitario de Toledo
NOT_YET_RECRUITINGToledo, Spain
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Hospital Universitario de la Princesa
RECRUITINGMadrid, Spain
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Hospital Vega Baja
RECRUITINGOrihuela, Alicante, Spain
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Isoflurane (inhaled) and Propofol (intravenous)
What this could lead to
If it works, this could show that inhaled sedation helps patients come off ventilators faster and spend less time in the ICU.
What could go wrong
This is a phase 4 trial, but it's still early to know if inhaled sedation is truly better. Results may not apply to all ICU patients, and there are risks like breathing problems or heart issues.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.