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Hidden danger: deadly fungus strikes flu patients in ICU

NCT ID NCT07330986

Knowledge-focused Sponsor: Jianfeng Xie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study reviewed records from 542 adults in 20 ICUs across China who had severe flu (Influenza A) and breathing failure. Researchers divided patients into those who also developed a fungal lung infection (aspergillosis) and those who did not, to understand risk factors and survival rates. The goal is to help doctors spot and treat this dangerous co-infection earlier.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors identify which flu patients are at highest risk for a deadly fungal co-infection, leading to earlier treatment and better survival.
What could go wrong
This is a retrospective (looking back at past records) study, so it can show links but cannot prove cause and effect. Results may not apply to all hospitals or countries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

542 people

The number who actually took part.

Started

Nov 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients admitted to the ICU between November 1, 2024, and February 28, 2025, with acute respiratory failure due to laboratory-confirmed Influenza A pneumonia

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adult patients (≥18 years) * patients admitted to the ICU between November 1, 2024, and February 28, 2025 * patients with acute respiratory failure due to laboratory-confirmed Influenza A pneumonia (defined by a positive PCR test on respiratory specimens) Exclusion Criteria: * patients with readmission to the ICU * patients with incomplete clinical data

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Conditions

The condition(s) this trial relates to.

invasive aspergillosis Invasive Pulmonary Aspergillosis swine influenza

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ICU Influenza A Invasive pulmonary aspergillosis

Contacts and locations

Locations

  • Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Southeast University

    Nanjing, China

More trials for these conditions

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