Brain zapping tailored to you: new hope for joyless depression?

This study tested a noninvasive brain stimulation technique called accelerated intermittent theta burst stimulation (aiTBS) for people with anhedonic depression—a type of depression where you lose interest or pleasure in things. 60 adults were randomly assigned to receive either a personalized version based on their own brain activity, a standard version, or a placebo (sham) treatment over one week. The goal was to see if personalizing the stimulation could better improve depression and anhedonia symptoms.