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New hope for Hard-to-Treat breast cancer: Head-to-Head drug trial launches

NCT ID NCT05646862

Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 2 times

Summary

This Phase 3 study tests whether a new drug, inavolisib, combined with fulvestrant works better than the current standard alpelisib plus fulvestrant for people with a specific type of advanced breast cancer (HR-positive, HER2-negative, with a PIK3CA mutation). The trial enrolled 420 participants whose cancer had worsened despite prior treatment. The main goal is to see how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
inavolisib and fulvestrant
What this could lead to
If successful, this could provide a more effective treatment option for people with a specific type of advanced breast cancer that has stopped responding to current therapies.
What could go wrong
This is a Phase 3 trial, but results are not yet available. The new drug combination may not prove better than the existing one, and side effects could be similar or worse.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 420 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2023

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Main Study and Sub-study: * If pre/perimenopausal women and men treatment with luteinizing hormone-releasing hormone (LHRH) agonist therapy beginning at least 2 weeks prior to Day 1 of Cycle 1 * Histologically or cytologically confirmed adenocarcinoma of the breast that is locally advanced or metastatic and is not amenable to surgical or radiation therapy with curative intent * Documented HR +/ HER2- tumor according to American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines * Confirmation of biomarker eligibility: detection of specified mutation(s) of PIK3CA via specified test * Disease progression after or during treatment with a combination of CDK4/6i and endocrine therapy: \<= 2 prior lines of systemic therapy in mBC setting; CDK4/6i based therapy does not need to be the last one received prior study entry; one line of chemotherapy in mBC setting allowed * Measurable or evaluable disease per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) * Participants for whom endocrine-based therapy is recommended and treatment with cytotoxic chemotherapy is not indicated at time of entry into the study, as per national or local treatment guidelines * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or 2 * Life expectancy of \> 6 months * Adequate hematologic and organ function prior to initiation of study treatment Exclusion Criteria for both Main Study and Sub-study: * Metaplastic breast cancer * Prior treatment in locally advanced or metastatic setting with any PI3K, AKT, or mTOR inhibitor or any agent whose mechanism of action is to inhibit the PI3K/-AKT/-mTOR pathway * Participant who relapsed with documented evidence of progression \> 12 months from completion of adjuvant CDK4/6i based therapy with no treatment for metastatic disease * Type 2 diabetes requiring ongoing systemic treatment at the time of study entry; or any history of Type 1 diabetes * Inability or unwillingness to swallow pills * Malabsorption syndrome or other condition that would interfere with enteral absorption * Any history of leptomeningeal disease or carcinomatous meningitis * Known and untreated, or active central nervous system (CNS) metastases. Participants with a history of treated CNS metastases are eligible if they meet specific certain criteria * Any concurrent ocular or intraocular condition that, in the opinion of the investigator, would require medical or surgical intervention during the study period to prevent or treat vision loss that might result from that condition * Active inflammatory or infectious conditions in either eye or history of idiopathic or autoimmune-associated uveitis in either eye * Requirement for daily supplemental oxygen * Symptomatic active lung disease, including pneumonitis * History of or active inflammatory bowel disease * Any active bowel inflammation * Clinically significant and active liver disease, including severe liver impairment, viral or other hepatitis, current alcohol abuse, or cirrhosis * Participants with known human immunodeficiency virus infection that meet specific criteria * History of other malignancy within 5 years prior to screening, except for cancers with very low risk of recurrence * Chronic therapy of \>= 10 mg of prednisone per day or an equivalent dose of other anti-inflammatory corticosteroids or immunosuppressants for a chronic disease * Active ongoing osteonecrosis of the jaw Exclusion Criteria for Main Study Only: * Pregnant, lactating, or breastfeeding, or intending to become pregnant during the study or at least 60 days after the final dose of study treatment * Known active, systemic infection at study enrollment, or any major episode of infection requiring treatment with intravenous antibiotics or hospitalization within 7 days prior to Day 1 of Cycle 1 * Investigational drug(s) within 4 weeks before randomization or within 5 half-lives of the investigational drug(s), whichever is longer * Allergy or hypersensitivity to components or excipients of the inavolisib, fulvestrant, or alpelisib formulations * History of severe cutaneous reactions like Stevens-Johnson Syndrome, Erythema Multiforme, Toxic Epidermal Necrolysis, or Drug Reaction with Eosinphilia and Systemic Symptoms Exclusion Criteria for Sub-study Only: * Pregnant, lactating, or breastfeeding, or intending to become pregnant during the substudy or within 2 weeks after the final dose of inavolisib and within 2 years after the final dose of fulvestrant, whichever is longer * Known active, systemic infection at study enrollment, or any major episode of infection requiring treatment with intravenous antibiotics or hospitalization within 7 days prior to Day -4 of Cycle 1 * Investigational drug(s) within 4 weeks prior to Day -4 or within 5 half-lives of the investigational drug(s), whichever is longer * Allergy or hypersensitivity to components or excipients of the inavolisib, fulvestrant formulations * Treatment with mild, moderate, or strong inducers of CYP2B6, CYP3A4, and/or CYP2C19 (including St. John's Wort) within 14 days or 5 drug-elimination half-lives, whichever is longer, prior to initiation of study treatment on Day -4 until after the final PK sample has been collected on Day 15 of Cycle 1 * Treatment with mild, moderate, or strong inhibitors of CYP2B6, CYP3A4, and/or CYP2C19 (including grapefruit juice or supplements) within 14 days or 5 drug-elimination half-lives, whichever is longer, prior to initiation of study treatment on Day -4 until after the final PK sample has been collected on Day 15 of Cycle 1

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • A.O. S. Anna e San Sebastiano

    ACTIVE_NOT_RECRUITING

    Caserta, Campania, 81100, Italy

  • AOU Città della Salute e della Scienza di Torino

    WITHDRAWN

    Turin, Piedmont, 10126, Italy

  • ARKE Estudios Clínicos S.A. de C.V.

    ACTIVE_NOT_RECRUITING

    Mexico City, Mexico CITY (federal District), 06700, Mexico

  • ASL AL - Azienda Sanitaria Locale AL

    WITHDRAWN

    Alessandria, Piedmont, 15121, Italy

  • AUSL della Romagna

    WITHDRAWN

    Ravenna, Emilia-Romagna, 48121, Italy

  • Abramson Cancer Center Chester County Hospital

    WITHDRAWN

    West Chester, Pennsylvania, 19380, United States

  • Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde

    ACTIVE_NOT_RECRUITING

    Morelia, 58260, Mexico

  • Arthur J.E. Child Comprehensive Cancer Center-Calgary

    ACTIVE_NOT_RECRUITING

    Calgary, Alberta, T2N 5G2, Canada

  • Asan Medical Center

    ACTIVE_NOT_RECRUITING

    Seoul, 05505, South Korea

  • Asante Rogue Regional Medical Center

    COMPLETED

    Medford, Oregon, 97504-8332, United States

  • BC Cancer ? Vancouver

    COMPLETED

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Banner MD Anderson Cancer Center

    WITHDRAWN

    Greeley, Colorado, 85234, United States

  • Basingstoke and North Hampshire Hospital

    WITHDRAWN

    Basingstoke, RG24 9NA, United Kingdom

  • Bendigo Cancer Centre

    ACTIVE_NOT_RECRUITING

    Bendigo, Victoria, 3550, Australia

  • Blackpool Victoria Hospital

    ACTIVE_NOT_RECRUITING

    Blackpool, FY3 8NR, United Kingdom

  • Brustzentrum Rhein-Ruhr Servicegesellschaft mbH

    ACTIVE_NOT_RECRUITING

    Mönchengladbach, 41061, Germany

  • Bryn Mawr Hospital

    WITHDRAWN

    Bryn Mawr, Pennsylvania, 19010-3121, United States

  • CENEIT Oncologicos

    COMPLETED

    Mexico City, 03100, Mexico

  • CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica

    COMPLETED

    San Juan, J5400DIL, Argentina

  • CHA Bundang Medical Center

    WITHDRAWN

    Gyeonggi-do, 13496, South Korea

  • CIUSSS de l Est de l Ile de Montreal - Hopital Maisonneuve Rosemont

    COMPLETED

    Montreal, Quebec, H1T 2M4, Canada

  • COI Centro Oncologico Internacional Santa Fe

    COMPLETED

    Mexico City, Mexico CITY (federal District), 01330, Mexico

  • Campbelltown Hospital

    WITHDRAWN

    Campbelltown, New South Wales, 2560, Australia

  • Cancer & Hematology Centers of Western Michigan

    COMPLETED

    Grand Rapids, Michigan, 49503, United States

  • Cancer Blood and Specialty Clinic

    ACTIVE_NOT_RECRUITING

    Los Alamitos, California, 90720, United States

  • Cancer Care Centers of Brevard

    WITHDRAWN

    Palm Bay, Florida, 32901, United States

  • Catholic Univ. of Incheon St.Mary's Hospital

    WITHDRAWN

    Incheon, 21431, South Korea

  • Centre Eugene Marquis

    ACTIVE_NOT_RECRUITING

    Rennes, 35042, France

  • Centre Hospitalier de La Cote Basque

    ACTIVE_NOT_RECRUITING

    Bayonne, 64109, France

  • Centre Hospitalier de l'Universite de Montreal (CHUM)

    COMPLETED

    Montreal, Quebec, H2X 0C2, Canada

  • Centre Leon Berard

    ACTIVE_NOT_RECRUITING

    Lyon, 69008, France

  • Centro Oncologico Korben

    ACTIVE_NOT_RECRUITING

    Ciudad Autonoma Buenos Aires, C1426AGE, Argentina

  • Centro de Investigaciones Médicas y Desarrollo LC S.R.L

    COMPLETED

    Buenos Aires, C1113AAE, Argentina

  • Centrum Onkologii im. Prof. Franciszka ?ukaszczyka

    COMPLETED

    Bydgoszcz, 85-796, Poland

  • Chang Gung Memorial Hosipital at Linkou

    COMPLETED

    Taoyuan City, 333, Taiwan

  • China Medical University Hospital

    ACTIVE_NOT_RECRUITING

    Taichung, 404, Taiwan

  • Chulabhorn Hospital

    WITHDRAWN

    Lak Si, 10210, Thailand

  • Chulalongkorn Hospital

    WITHDRAWN

    Bangkok, 10330, Thailand

  • Churchill Hospital

    ACTIVE_NOT_RECRUITING

    Oxford, OX3 7LE, United Kingdom

  • Cleveland Clinic Florida

    ACTIVE_NOT_RECRUITING

    Weston, Florida, 33331, United States

  • Clinica Viedma S.A.

    COMPLETED

    Viedma, R8500ACE, Argentina

  • Clinique Ste-Elisabeth

    ACTIVE_NOT_RECRUITING

    Namur, 5000, Belgium

  • Cliniques Universitaires St-Luc

    ACTIVE_NOT_RECRUITING

    Brussels, 1200, Belgium

  • Coffs Harbour Health Campus

    ACTIVE_NOT_RECRUITING

    Coffs Harbour, New South Wales, 2450, Australia

  • Complejo Hospitalario Universitario de Santiago (CHUS)

    WITHDRAWN

    Santiago de Compostela, LA Coruna, 15706, Spain

  • Concord Repatriation General Hospital

    ACTIVE_NOT_RECRUITING

    Concord, New South Wales, 2139, Australia

  • Cross Cancer Institute

    ACTIVE_NOT_RECRUITING

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dicle University Faculty of Medicine

    COMPLETED

    Diyarbakır, 21280, Turkey (Türkiye)

  • Dr. W.M. Szpak Incorporated trading as Rainbow Oncology

    WITHDRAWN

    Durban, 4126, South Africa

  • Dumfries and Galloway Royal Infirmary

    WITHDRAWN

    Dumfries, DG1 4AP, United Kingdom

  • Eastern CT Hematology and Oncology Associates

    WITHDRAWN

    Norwich, Connecticut, 06360-2740, United States

  • Ege Uni Medical Faculty Hospital

    ACTIVE_NOT_RECRUITING

    Izmir, 35100, Turkey (Türkiye)

  • Emory University Hospital

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • First Affiliated Hospital of Medical College of Xi'an Jiaotong University

    ACTIVE_NOT_RECRUITING

    Xi'an, 710061, China

  • Fundacion CORI para la Investigacion y Prevencion del Cancer

    COMPLETED

    La Rioja, F5300COE, Argentina

  • GHdC Site Les Viviers

    COMPLETED

    Charleroi, 6000, Belgium

  • Gabrail Cancer Center

    WITHDRAWN

    Canton, Ohio, 44718, United States

  • Gangnam Severance Hospital

    ACTIVE_NOT_RECRUITING

    Seoul, 06273, South Korea

  • Gosford Hospital

    COMPLETED

    Gosford, New South Wales, 2250, Australia

  • Goztepe Prof.Dr. Suleyman Yalcin City Hospital

    COMPLETED

    Kadiköy, 34722, Turkey (Türkiye)

  • Grady Health System

    ACTIVE_NOT_RECRUITING

    Atlanta, Georgia, 30303, United States

  • Guangdong Provincial People's Hospital

    ACTIVE_NOT_RECRUITING

    Guangzhou, 510180, China

  • Gulhane Training and Applicaton Hospital

    ACTIVE_NOT_RECRUITING

    Ankara, 06010, Turkey (Türkiye)

  • Hacettepe Uni Medical Faculty Hospital

    ACTIVE_NOT_RECRUITING

    Sihhiye/Ankara, 06230, Turkey (Türkiye)

  • Harbin Medical University Tumor Hospital

    COMPLETED

    Harbin, 150049, China

  • Health Pharma Professional Research

    COMPLETED

    Mexico City, Mexico CITY (federal District), 03100, Mexico

  • Hopelands Cancer Centre

    WITHDRAWN

    Hilton, 3245, South Africa

  • Hosp Provincial D. Centenarios

    ACTIVE_NOT_RECRUITING

    Rosario, S2002KDS, Argentina

  • Hospital General Universitario Gregorio Marañon

    ACTIVE_NOT_RECRUITING

    Madrid, 28007, Spain

  • Hospital Ramon y Cajal

    ACTIVE_NOT_RECRUITING

    Madrid, 28034, Spain

  • Hospital Regional Universitario Carlos Haya

    COMPLETED

    Málaga, 29011, Spain

  • Hospital San Pedro De Alcantara

    COMPLETED

    Cáceres, 10003, Spain

  • Hospital Santa Cruz / Centro de Oncologia D'Or

    RECRUITING

    Curitiba, Paraná, 80420-090, Brazil

  • Hospital Sao Lucas - PUCRS

    WITHDRAWN

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Hospital Sírio-Libanês

    ACTIVE_NOT_RECRUITING

    São Paulo, São Paulo, 01308-050, Brazil

  • Hospital Universitari Vall d'Hebron

    WITHDRAWN

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    ACTIVE_NOT_RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario Virgen Macarena

    ACTIVE_NOT_RECRUITING

    Seville, 41009, Spain

  • Hospital Universitario Virgen de Arrixaca

    WITHDRAWN

    Murcia, 30120, Spain

  • Hospital Universitario de Canarias

    ACTIVE_NOT_RECRUITING

    San Cristóbal de La Laguna, Tenerife, 38320, Spain

  • Hospital da Bahia

    WITHDRAWN

    Salvador, Estado de Bahia, 41810-011, Brazil

  • Hospital de Base de Sao Jose do Rio Preto

    RECRUITING

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Hospital do Cancer de Pernambuco - HCP

    COMPLETED

    Recife, Pernambuco, 50040-000, Brazil

  • Hubei Cancer Hospital

    ACTIVE_NOT_RECRUITING

    Wuhan, 430079, China

  • Humanitas Centro Catanese Di Oncologia

    WITHDRAWN

    Misterbianco (CT), Sicily, 95045, Italy

  • Hôpital du Sacré-Coeur de Montreal

    COMPLETED

    Montreal, Quebec, H4J 1C5, Canada

  • ICM

    ACTIVE_NOT_RECRUITING

    Montpellier, 34298, France

  • ICO L'Hospitalet

    ACTIVE_NOT_RECRUITING

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola

    ACTIVE_NOT_RECRUITING

    Meldola, Emilia-Romagna, 47014, Italy

  • IUCT Oncopole

    ACTIVE_NOT_RECRUITING

    Toulouse, 31100, France

  • Icon Cancer Care Wesley

    COMPLETED

    Auchenflower, Queensland, 4066, Australia

  • Inha University Hospital

    WITHDRAWN

    Incheon, 22332, South Korea

  • Institut Sainte Catherine

    WITHDRAWN

    Avignon, 84082, France

  • Instituto D?Or de Pesquisa e Ensino ? Hospital DF STAR

    WITHDRAWN

    Brasília, Federal District, 70390-140, Brazil

  • Instituto D?Or de Pesquisa e Ensino ? Hospital Esperança Recife

    ACTIVE_NOT_RECRUITING

    Recife, Pernambuco, Brazil

  • Instituto Nacional de Cancerologia

    COMPLETED

    Distrito Federal, 14080, Mexico

  • Instituto de Oncología de Rosario

    ACTIVE_NOT_RECRUITING

    Rosario, S2000KZE, Argentina

  • Irccs Centro Di Riferimento Oncologico (CRO)

    WITHDRAWN

    Aviano, Friuli Venezia Giulia, 33081, Italy

  • Izmir Ataturk Training and Research Hospital

    ACTIVE_NOT_RECRUITING

    Izmir, 35360, Turkey (Türkiye)

  • Jewish General Hospital

    COMPLETED

    Montreal, Quebec, H3T 1E2, Canada

  • Jiangsu Cancer Hospital

    ACTIVE_NOT_RECRUITING

    Nanjing, 211100, China

  • Juravinski Hospital

    COMPLETED

    Hamilton, Ontario, L8V 5C2, Canada

  • Kadlec Clinic Hematology and Oncology

    WITHDRAWN

    Kennewick, Washington, 99336-7774, United States

  • Karmanos Cancer Institute.

    WITHDRAWN

    Detroit, Michigan, 48201, United States

  • Kinghorn Cancer Centre

    ACTIVE_NOT_RECRUITING

    Darlinghurst, New South Wales, 2010, Australia

  • Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt

    WITHDRAWN

    München, 80336, Germany

  • Korea University Anam Hospital

    ACTIVE_NOT_RECRUITING

    Seoul, 02841, South Korea

  • Kyungpook National University Chilgok Hospital

    COMPLETED

    Daegu, 41404, South Korea

  • Lankenau Medical Center, Cancer Center

    WITHDRAWN

    Wynnewood, Pennsylvania, 19096, United States

  • Liga Norte Riograndense Contra O Câncer

    COMPLETED

    Natal, Rio Grande do Norte, 59040150, Brazil

  • Los Angeles Cancer Network

    ACTIVE_NOT_RECRUITING

    Los Angeles, California, 90017-4803, United States

  • Lumi Research

    WITHDRAWN

    Kingwood, Texas, 77339, United States

  • MD Anderson Cancer Center at Cooper

    WITHDRAWN

    Camden, New Jersey, 08103, United States

  • MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie

    ACTIVE_NOT_RECRUITING

    Rzeszów, 35-021, Poland

  • MVZ für Hämatologie und Onkologie Ravensburg GmBH

    WITHDRAWN

    Ravensburg, 88212, Germany

  • Maharaj Nakorn Chiang Mai Hospital

    WITHDRAWN

    Chiang Mai, 50200, Thailand

  • Maidstone & Tonbridge Wells Hospital

    COMPLETED

    Maidstone, ME16 9QQ, United Kingdom

  • Main Line Health System

    WITHDRAWN

    Wynnewood, Pennsylvania, 19096, United States

  • Mammazentrum Hamburg am Krankenhaus Jerusalem

    ACTIVE_NOT_RECRUITING

    Hamburg, 20357, Germany

  • Marin Cancer Care Inc

    WITHDRAWN

    Greenbrae, California, 94904, United States

  • Marmara Uni Faculty of Medicine

    COMPLETED

    Istanbul, 34890, Turkey (Türkiye)

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Medical Oncology Centre of Rosebank

    COMPLETED

    Johannesburg, 2196, South Africa

  • Medical Park Seyhan Hospital

    WITHDRAWN

    Seyhan, 01140, Turkey (Türkiye)

  • Medipol Mega Üniversite Hastanesi Göztepe

    COMPLETED

    Istanbul, 34214, Turkey (Türkiye)

  • Medizinische Hochschule Zentrum Frauenheilkunde Abt.Gynäkologische Onkologie

    ACTIVE_NOT_RECRUITING

    Hanover, 30625, Germany

  • Memorial Ankara Hastanesi

    ACTIVE_NOT_RECRUITING

    Ankara, 06520, Turkey (Türkiye)

  • Midtown West Medical

    ACTIVE_NOT_RECRUITING

    Atlanta, Georgia, 30318, United States

  • Minnesota Oncology Hematology

    ACTIVE_NOT_RECRUITING

    Saint Paul, Minnesota, 55102, United States

  • Mount Vernon & Watford Hospital Trust

    ACTIVE_NOT_RECRUITING

    Northwood, HA6 2RN, United Kingdom

  • Mountain View Oncology

    WITHDRAWN

    Paarl, 7646, South Africa

  • NUPEC

    COMPLETED

    Belo Horizonte, Minas Gerais, 30210-090, Brazil

  • Narodowy Instytut Onkologii Odzia? w Gliwicach

    ACTIVE_NOT_RECRUITING

    Gliwice, 44-102, Poland

  • Narodowy Instytut Onkologii im. M.Sklodowskiej-Curie

    ACTIVE_NOT_RECRUITING

    Warsaw, 02-781, Poland

  • National Cancer Center

    ACTIVE_NOT_RECRUITING

    Goyang-si, 10408, South Korea

  • National Cheng Kung University Hospital

    ACTIVE_NOT_RECRUITING

    Tainan, 70457, Taiwan

  • National Taiwan University Hospital

    ACTIVE_NOT_RECRUITING

    Zhongzheng Dist., 10048, Taiwan

  • Nationales Centrum für Tumorerkrankungen (NCT)

    COMPLETED

    Heidelberg, 69120, Germany

  • New Zealand Clinical Research - Auckland

    RECRUITING

    Auckland, 1010, New Zealand

  • Niels-Stensen-Kliniken Franziskus-Hospital Harderberg GmbH

    WITHDRAWN

    Georgsmarienhütte, 49124, Germany

  • Novant Health Forsyth Medical Center

    WITHDRAWN

    Winston-Salem, North Carolina, 27103, United States

  • Novant Health Presbyterain Medical Center

    WITHDRAWN

    Charlotte, North Carolina, 28204, United States

  • OncoMed

    ACTIVE_NOT_RECRUITING

    Mexico City, Mexico CITY (federal District), 03100, Mexico

  • Onkologische Schwerpunktpraxis Bielefeld

    WITHDRAWN

    Bielefeld, 33604, Germany

  • Ospedale Di Macerata

    WITHDRAWN

    Province of Macerata, The Marches, 62100, Italy

  • Ospedale S. Giuseppe

    WITHDRAWN

    Empoli (FI), Tuscany, 50053, Italy

  • Ospedale San Raffaele

    ACTIVE_NOT_RECRUITING

    Milan, Lombardy, 20132, Italy

  • Ospedale Santa Chiara

    COMPLETED

    Trento, Trentino-Alto Adige, 38100, Italy

  • Panamerican Clinical Research S.A de C.V.

    ACTIVE_NOT_RECRUITING

    Guadalajara, Jalisco, 44670, Mexico

  • Paoli Memorial Hospital

    WITHDRAWN

    Paoli, Pennsylvania, 19301, United States

  • Polyclinique Bordeaux Nord

    WITHDRAWN

    Bordeaux, 33300, France

  • Praxis für Interdisziplinäre Onkologie und Hämatologie GbR

    ACTIVE_NOT_RECRUITING

    Freiburg im Breisgau, 79110, Germany

  • Princess Alexandra Hospital

    ACTIVE_NOT_RECRUITING

    Harlow, CM20 1QX, United Kingdom

  • Przychodnia Lekarska KOMED, Roman Karaszewski

    COMPLETED

    Konin, 62-500, Poland

  • RENATI INNOVATION S.A.P.I. de C.V

    COMPLETED

    Guadalajara, Jalisco, 44680, Mexico

  • Richards Bay Oncology Centre

    COMPLETED

    KwaZulu Natal, 3900, South Africa

  • Rocky Mountain Cancer Centers

    COMPLETED

    Denver, Colorado, 80220, United States

  • Royal Hampshire County Hospital

    WITHDRAWN

    Winchester, SO22 5DG, United Kingdom

  • Royal Preston Hosptial

    WITHDRAWN

    Preston, PR2 9HT, United Kingdom

  • Samsung Medical Center

    ACTIVE_NOT_RECRUITING

    Seoul, 06351, South Korea

  • Sanatorio Parque S.A.

    WITHDRAWN

    Rosario, S2000QGB, Argentina

  • Santa Casa de Misericordia de Porto Alegre

    ACTIVE_NOT_RECRUITING

    Porto Alegre, Rio Grande do Sul, 90050-170, Brazil

  • Seoul National University Hospital

    ACTIVE_NOT_RECRUITING

    Seoul, 03080, South Korea

  • Seoul St Mary's Hospital

    ACTIVE_NOT_RECRUITING

    Seoul, 06591, South Korea

  • Severance Hospital, Yonsei University Health System

    ACTIVE_NOT_RECRUITING

    Seoul, 03722, South Korea

  • Shandong Cancer Hospital

    WITHDRAWN

    Jinan, 250117, China

  • Sichuan Provincial Cancer Hospital

    COMPLETED

    Chengdu, 610041, China

  • Sir Charles Gairdner Hospital

    ACTIVE_NOT_RECRUITING

    Perth, Western Australia, 6009, Australia

  • Sir Run Run Shaw Hospital Zhejiang University

    COMPLETED

    Hangzhou, 310016, China

  • Songklanagarind Hospital

    WITHDRAWN

    Songkhla, 90110, Thailand

  • St Bartholomew's Hospital

    COMPLETED

    London, EC1M 6BQ, United Kingdom

  • St John's Hospital

    WITHDRAWN

    Livingston, EH54 6PP, United Kingdom

  • St. Lukes Hospital and Health Network

    WITHDRAWN

    Easton, Pennsylvania, 18045, United States

  • St. Vincenz-Krankenhaus GmbH Paderborn Frauen- und Kinderklinik St. Louise

    ACTIVE_NOT_RECRUITING

    Paderborn, 33098, Germany

  • Sun yat-sen University Cancer Center

    COMPLETED

    Guangzhou, 510060, China

  • Szpital Morski im.PCK

    WITHDRAWN

    Gdynia, 81-519, Poland

  • Szpital Uniwersytecki w Krakowie

    ACTIVE_NOT_RECRUITING

    Krakow, 31-501, Poland

  • Szpital Wojewódzki im. Miko?aja Kopernika

    ACTIVE_NOT_RECRUITING

    Koszalin, 75-581, Poland

  • Taipei Veterans General Hospital

    COMPLETED

    Taipei, 11217, Taiwan

  • Texas Oncology (Flower Mound) - USOR

    WITHDRAWN

    Flower Mound, Texas, 75028, United States

  • Texas Oncology - Dallas Presbyterian Hospital

    ACTIVE_NOT_RECRUITING

    Dallas, Texas, 75231, United States

  • Texas Oncology McKinney

    WITHDRAWN

    McKinney, Texas, 75071, United States

  • Texas Oncology West

    WITHDRAWN

    Amarillo, Texas, 79106, United States

  • Texas Tech University Health Sciences Center

    WITHDRAWN

    El Paso, Texas, 79905, United States

  • The Center for Cancer and Blood Disorders - Fort Worth

    WITHDRAWN

    Fort Worth, Texas, 76104, United States

  • The First Affiliated Hospital, Chongqing Medical University

    WITHDRAWN

    Chongqing, 400016, China

  • The First Hospital of Jilin University

    COMPLETED

    Changchun, 130021, China

  • The Moncton Hospital

    ACTIVE_NOT_RECRUITING

    Moncton, New Brunswick, E1C 6Z8, Canada

  • The Ottawa Hospital - General Campus

    ACTIVE_NOT_RECRUITING

    Ottawa, Ontario, K1Y 4E9, Canada

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    COMPLETED

    Hangzhou, 310009, China

  • The Second Affiliated Hospital to Nanchang University

    ACTIVE_NOT_RECRUITING

    Nanchang, 330006, China

  • Tianjin Cancer Hospital

    ACTIVE_NOT_RECRUITING

    Tianjin, 300000, China

  • Trakya University Medical Faculty

    ACTIVE_NOT_RECRUITING

    Edirne, 22030, Turkey (Türkiye)

  • UC Davis Comprehensive Cancer Center

    ACTIVE_NOT_RECRUITING

    Sacramento, California, 95817, United States

  • UZ Antwerpen

    COMPLETED

    Edegem, 2650, Belgium

  • UZ Gent

    ACTIVE_NOT_RECRUITING

    Ghent, 9000, Belgium

  • UZ Leuven Gasthuisberg

    ACTIVE_NOT_RECRUITING

    Leuven, 3000, Belgium

  • Uniklinik RWTH Aachen Klinik für Gynäkologie und Geburtsmedizin

    COMPLETED

    Aachen, 52074, Germany

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    COMPLETED

    Wuhan, 430023, China

  • University of California, Irvine Medical Center

    WITHDRAWN

    Orange, California, 92868, United States

  • University of Louisville Hospital

    WITHDRAWN

    Louisville, Kentucky, 40202, United States

  • University of the Sunshine Coast

    WITHDRAWN

    Sippy Downs, Queensland, 4556, Australia

  • Universitätsklinikum Essen

    ACTIVE_NOT_RECRUITING

    Essen, 45122, Germany

  • Universitätsmedizin Göttingen Georg-August-Universität

    COMPLETED

    Göttingen, 37075, Germany

  • Vencer Oncoclínica - Centro de Pesquisa do Piauí

    WITHDRAWN

    Teresina, Piauí, 64049-200, Brazil

  • Veterans General Hospital - Taichung

    ACTIVE_NOT_RECRUITING

    Xitun Dist., 40705, Taiwan

  • WellSpan Oncology Research

    WITHDRAWN

    York, Pennsylvania, 17403, United States

  • Western General Hospital

    ACTIVE_NOT_RECRUITING

    Edinburgh, EH4 2XU, United Kingdom

  • Winship Cancer Institute at Emory Saint Joseph's Hospital

    ACTIVE_NOT_RECRUITING

    Atlanta, Georgia, 30342, United States

  • Zhejiang Cancer Hospital

    ACTIVE_NOT_RECRUITING

    Zhejiang, 310022, China

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